Actively Recruiting
Comprehensive Esophageal Diagnostics Study
Led by Emory University · Updated on 2025-11-10
80
Participants Needed
2
Research Sites
302 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry) after pharmacologic challenge. A better understanding of achalasia will allow intervention at an earlier stage.
CONDITIONS
Official Title
Comprehensive Esophageal Diagnostics Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients, age 18 and above
- Evaluated by Emory Digestive Diseases Clinic, Emory Motility Lab, the Emory Endoscopy Unit, or Emory Surgery Department starting October 1, 2020
- Diagnosis of achalasia or esophageal motility disorder confirmed by FLIP or high-resolution esophageal manometry
- Undergoing diagnostic FLIP study at Emory University Hospital with anesthesia assistance
- Undergoing Heller myotomy or per-oral endoscopic myotomy for treatment of esophageal motility disorder
You will not qualify if you...
- Patients younger than 18 years old
- Pregnant women
- Prisoners
- Non-English speaking
- Cognitively impaired adults unable to provide informed consent
- Cardiac disease including arrhythmia requiring ICD or pacemaker, baseline bradycardia with heart rate less than 60 or tachycardia with heart rate greater than 90, congestive heart failure with ejection fraction less than 35%, history of myocardial infarction, baseline mean arterial pressure less than 65 or systolic blood pressure greater than 140
- Asthma or chronic obstructive pulmonary disease
- Urinary retention requiring use of foley catheterization
- Narrow-angle glaucoma
- Myasthenia gravis
- Glomerular filtration rate less than 60 (for Aim 1 only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
2
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
Research Team
A
Anand Jain, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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