Study of Esophageal Muscle Changes and Function in Achalasia Using New Measurement Technology

What this Trial Is About

Researchers are investigating achalasia, a condition where the lower esophageal sphincter LES does not open properly. The study aims to better understand muscle fibrosis in relation to LES function using a new technology called Functional Lumen Imaging Probe FLIP Topography, which measures LES activity after medication. This research could help identify achalasia earlier and improve treatment options. Participants will undergo an atropine challenge, where they receive an intravenous dose of atropine at 15 mcgkg. LES measurements will be taken before and two minutes after drug administration using FLIP. Some participants who are having surgery for their esophageal disorder will also have muscle biopsies taken from the LES and distal esophagus to examine collagen content. During the study, researchers will assess LES contraction and relaxation two minutes after drug administration, along with collagen levels in muscle biopsy samples. Participants will have procedures including FLIP measurements and possibly muscle biopsy during surgery. The study is conducted without blinding or placebo and involves monitoring physiological responses to the atropine challenge to better characterize achalasia.

Comprehensive Esophageal Diagnostics Study