Actively Recruiting
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
Led by Ohio State University Comprehensive Cancer Center · Updated on 2026-04-06
1500
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
Sponsors
O
Ohio State University Comprehensive Cancer Center
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) vs. non-tobacco flavored ECs vs. nicotine replacement therapy (patches and lozenges) on smoking behavior in current cigarette smokers. ECs may reduce cigarette craving and withdrawal symptoms, increase motivation and confidence to stop cigarette smoking, and decrease cigarette smoking and dependence. By comparing participants' preferred flavor ECs (PEC) to tobacco flavor ECs (TEC) to NRT, researchers hope to determine the effect of EC flavors on appeal and use and learn how ECs affect smoking behaviors and health.
CONDITIONS
Official Title
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years or older
- Smoke 5 or more cigarettes daily for at least the past year
- Willing to use either an electronic cigarette or nicotine replacement therapy
- Able to read and speak English
- Have access to a smartphone
You will not qualify if you...
- Currently using smoking cessation medications, nicotine replacement therapy, or seeking treatment to quit smoking
- Use electronic cigarettes more than 4 days per month
- Diagnosed with lung disease, asthma, cystic fibrosis, heart disease, or chronic obstructive pulmonary disease (COPD)
- Have unmanaged schizophrenia (unmedicated or without counseling)
- History of cardiac events or distress within the past 3 months
- Currently pregnant, planning pregnancy within 6 months, or breastfeeding
- High blood pressure not controlled by medication
- Serious angina pectoris or chest pain
- Stroke within the past 3 months
- Known allergy to propylene glycol or vegetable glycerin
- Serious heart rhythm problems or arrhythmias
- Living in the same household as another study participant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
T
The Ohio State Comprehensive Cancer Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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