Comprehensive Molecular Profiling and Tissue Collection for Pediatric and Adult Tumors Including Solid Tumors and Familial Cancer Syndromes

What this Trial Is About

Researchers are conducting a study to develop a tissue repository for collecting and storing blood, serum, tissue, urine, and tumor samples from children and adults diagnosed with common childhood cancers, such as leukemia and central nervous system tumors. The study aims to improve understanding of cancer biology and support research into new therapies through comprehensive molecular, genomic, proteomic, and metabolomic profiling. This includes patients with tumors, pre-malignant disorders, suspected cancer susceptibility syndromes, and their biological relatives, as well as healthy volunteers undergoing routine care. The study collects extra biological samples, such as blood, serum, tissue, urine, or tumors, during medically necessary procedures or approved research studies without additional risk. Samples may be obtained from patients at any age with malignancies or pre-malignancies, their relatives, and healthy volunteers during surgeries or routine visits. Collected specimens are used for advanced analyses including DNA, RNA, protein extraction, immune profiling, and growth factor investigations. The repository supports future research by storing these samples and overseeing their distribution to investigators. Participants provide consent to allow use of their samples for genomic and molecular research. Sample collection is done alongside standard medical care, minimizing risk and avoiding extra procedures solely for research purposes. The study measures include ongoing tissue analysis and may involve interviews with parents or caregivers about knowledge and attitudes related to genetic testing for pediatric cancer. Participation duration varies as samples are collected during routine care visits or approved studies, with an expected enrollment of 100-150 patients annually.

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies