Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States.
M S Linet, L A Ries, M A Smith...
https://pubmed.ncbi.nlm.nih.gov/10379968Actively Recruiting
Age: 4Weeks +
All Genders
Healthy Volunteers
ID01109394
Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
Led by National Cancer Institute (NCI) · Updated on 2026-05-22
6035
Participants Needed
5
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying common childhood cancers and related cancers in adults through collecting and storing biological samples such as blood, serum, tissue, urine, and tumors. The goal is to create a tissue repository that supports detailed molecular, genomic, proteomic, and metabolomic profiling to better understand cancer biology and support new therapies. This includes children, adolescents, and adults diagnosed with various tumors, malignancies, or suspected familial cancer syndromes. Participants will provide extra samples during times when medical care or research procedures already require sampling, without additional invasive procedures solely for the study. Samples collected include DNA, RNA, proteins, tumor and normal tissues, and blood from patients, relatives, and healthy volunteers. Various specialized tests and studies will be conducted on these samples, such as immune profiling, growth factor analysis, and establishing cell lines and xenografts for further research. The study also includes interviews with parents or caregivers about their views on genetic testing and treatment for pediatric cancer. Participants may be asked to provide samples and information during routine care or approved research visits. Samples and data will be used for ongoing tissue analysis and molecular studies. The study involves collection with minimal additional risk and includes healthy volunteers undergoing routine procedures. Parents or caregivers may also participate in interviews. The study is observational and ongoing, with the National Cancer Institute overseeing the sample repository and research use.
CONDITIONS
Brief Title
Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
Who Can Participate
Age: 4Weeks +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Pediatric or adult subjects diagnosed with any tumor, malignancy, pre-malignant disorder, or suspected familial cancer syndrome.
- Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial cancer syndrome.
- Healthy volunteers without a history of malignancy nor with family members currently being treated for cancer undergoing surgery, treatment, or well visits.
- Biospecimens can be collected with minimal additional risk during routine patient care procedures.
- Human samples, specimens, and data from IRB-approved closed protocols.
- Ability of the subject or legally authorized representative to understand and sign informed consent.
- Parent/caregiver of a pediatric or adult patient treated for pediatric cancer eligible for social and behavioral interviews.
- Must be able to give consent and understand English for interview participation.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Varies based on participant involvement and sample availability
Participants provide biological samples such as blood, tumor, and normal tissues for molecular, genomic, proteomic, and other advanced analyses using routine patient care procedures or existing specimen collections.
1 to 2 visits depending on procedures and sample availability
Behavioral Interviews
Duration - Single interview session
Parents or caregivers of pediatric or adult patients treated for pediatric cancer participate in social and behavioral interviews to assess knowledge, attitudes, beliefs, and behaviors regarding genomic testing.
1 visit (in-person or remote)
Long-term Monitoring
Duration - Ongoing as determined by research needs
Participants may be observed over time through additional sample collections or data analysis to support ongoing research activities without additional interventions.
Additional visits may occur depending on cohort assignment and research requirements
Trial Site Locations
Total: 5 locations
1
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Completed
2
Children's Hospital of Orange County (CHOC Children's)
Orange, Florida, United States, 92613
Withdrawn
3
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
4
Tisch Cancer Institute, Mount Sinai Medical Center
New York, New York, United States, 10029-0574
Withdrawn
5
Carolinas Medical Center/Levine Children's Hospital
Charlotte, North Carolina, United States, 28203
Withdrawn
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Research Team
D
Donna B Bernstein, R.N.
R
Rosandra N Kaplan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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J Khan, L H Saal, M L Bittner...
https://pubmed.ncbi.nlm.nih.gov/10197427