Abdominal-only Compression Garments Reduce Orthostatic Tachycardia and Improve Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome.
Kate M Bourne, Kavithra Karalasingham, Tanya Siddiqui...
https://pubmed.ncbi.nlm.nih.gov/41338488Actively Recruiting
Phase Not Applicable
Age: 18Years - 60Years
All Genders
ID04881318
Compression Garments in the Community With Postural Orthostatic Tachycardia Syndrome (POTS)
Led by University of Calgary · Updated on 2026-05-07
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of commercially available waist-high and abdominal compression garments for adults diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) to see if they improve heart rate and reduce symptoms in a community setting. POTS treatments include medications and non-drug methods like exercise and compression garments, but the effectiveness of everyday compression garments outside a lab is not well known. This trial aims to provide evidence on their practical use for managing POTS symptoms at home. Participants will use commercially or medically available waist-high compression tights applying 15-40 mmHg pressure, and optionally abdominal compression garments that cover the abdomen, buttocks, and upper thighs. The study includes two 2-day phases with a 5-day washout in between: one with regular medications affecting heart rate and blood pressure, and one without. Participants will be randomly assigned to wear compression garments with or without medications first, and for those in the abdominal compression sub-study, the order of garment use will also be randomized. During each study day, participants will wear a Holter monitor and perform four standing tests spaced by specific intervals before, during, and after wearing the compression garment. They will record symptoms and medications daily in a study booklet. Researchers will measure heart rate changes to assess the garments' effects. The total participation time is up to 4 days, with monitoring conducted in the participant's usual environment to reflect real-life use.
CONDITIONS
Brief Title
Compression Garments in the Community With POTS
Who Can Participate
Age: 18Years - 60Years
All Genders
Eligibility Criteria
You may qualify if you...
- Physician diagnosis of Postural Tachycardia Syndrome (POTS)
- Resident of Canada
- Owns waist-high compression garment: medical grade or commercially available tights with a pressure rating provided (e.g. 15-18 mmHg, 20-30 mmHg, 30-40 mmHg)
- Optional Sub-Study: owns an abdominal compression garment (e.g. abdominal shapewear, waist high shorts)
- Able to participate in a 4-day study (2x2 day segments with a 5-day washout period)
You will not qualify if you...
- Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease) that precludes POTS diagnosis
- Not a resident of Canada
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant (self-reported)
- Inability to tolerate compression garments for the duration of the study
- Does not own a waist-high compression garment
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 4 days in total
Participants will wear compression garments in the community setting to evaluate their effectiveness in reducing orthostatic tachycardia. They will undergo periods with and without their regular medications and complete standing tests while wearing a Holter monitor.
4 study days with 4 standing tests each day
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
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Research Team
K
Kate M Bourne, BSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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Published Research Related To This Trial
A Community-Based Trial of Commercially Available Compression Tights in Patients With Postural Orthostatic Tachycardia Syndrome.
Kate M Bourne, Kavithra Karalasingham, Tanya Siddiqui...
https://pubmed.ncbi.nlm.nih.gov/39614865