What is this study trying to find out about cognitive dysfunction after stroke, cardiac arrest, or Parkinson's disease?

This study is evaluating how specialized computer-based cognitive rehabilitation compares to general computer-based cognitive stimulation in improving executive functions. Researchers aim to understand which type of training better supports cognitive recovery in these patient groups. The study is sponsored by Bispebjerg Hospital and involves a randomized controlled design.

Who may be eligible for this cognitive dysfunction clinical trial?

Adults aged 18 to 100 years with a diagnosis of stroke, cardiac arrest, or Parkinson's disease may be eligible. Participants must have impaired working memory, access to a computer and internet at home, and provide informed consent. Specific criteria apply based on the condition, such as recent stroke or ongoing Parkinson's treatment. Please review eligibility criteria for more details.

Is there any cost to participate in this cognitive dysfunction clinical trial?

Study-related care, including the computer-based training and all trial visits, is provided at no cost. However, personal travel expenses to attend visits may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel needs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 100Years

All Genders

ID04229056

Computer-Assisted Self-Training to Improve Executive Function Versus Unspecific Training in Patients After Stroke, Cardiac Arrest, or Parkinsons Disease a Randomized Controlled Trial

Led by Bispebjerg Hospital · Updated on 2025-02-20

307

Participants Needed

Research Sites

25 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying the effects of specialized computer-based cognitive rehabilitation CBCR aimed at improving executive functions in patients who have experienced stroke, cardiac arrest, or have Parkinsons disease. The study compares this specialized CBCR to general computer-based cognitive stimulation activities to understand which approach better supports cognitive function. The trial involves 307 patients and explores cognitive outcomes, quality of life, and daily living abilities. Participants are randomly assigned to one of two groups. One group trains using 10 exercises from the Scientific Brain Training PRO software designed to enhance various executive functions. The other group completes 10 general cognitive stimulation games from a specially developed website that focus on overall concentration and visuoperceptual skills but place less demand on executive functions. Both groups train for 8 weeks, five days per week, with each session lasting 60 minutes. During the study, participants undergo neuropsychological testing at the start, immediately after the 8-week training period, and again three months later to assess executive functions. They also complete questionnaires about quality of life and daily activities at these same time points. Researchers monitor compliance with the training and measure outcomes like working memory, verbal fluency, and fear levels. The study includes safety and follow-up assessments over several months, tracking progress and any changes in cognitive and functional abilities.

CONDITIONS

Brief Title

COMPuter-assisted Self-training to Improve EXecutive Function

Who Can Participate

Age: 18Years - 100Years

All Genders

Eligibility Criteria

You may qualify if you...

Diagnosis of stroke, cardiac arrest, or Parkinson's disease
Aged 18 years or older
Impaired working memory with 5 symbols or less backwards on the CABPad test
Access to a computer and internet at home
Providing informed consent
Stroke patients included within 6 months post-stroke, confirmed by clinical findings and imaging, with initial stroke severity NIHSS 3 or higher
Cardiac arrest patients included within 6 months post ictus
Parkinson's disease patients with clinical diagnosis and receiving anti-parkinsonian medication

You will not qualify if you...

No informed consent provided
Other neurological or psychiatric diseases expected to affect participation
Unable to participate as judged by the investigator
Stroke patients with massive denial of executive dysfunction or severe aphasia affecting test performance
Parkinson's disease patients diagnosed with PD Dementia according to MDS criteria

Research Team

Hanne Christensen, Professor

Katrine Sværke, M.Sc. Psych.

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