Computer-Assisted Self-Training to Improve Executive Function in Adults with Stroke, Cardiac Arrest, or Parkinsons Disease A Randomized Controlled Trial Comparing Specialized and General Computer-Based Training
Led by Bispebjerg Hospital · Updated on 2025-02-20
307
Participants Needed
2
Research Sites
25 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the effects of specialized computer-based cognitive rehabilitation CBCR aimed at improving executive functions in patients who have experienced stroke, cardiac arrest, or have Parkinsons disease. The study compares this specialized CBCR to general computer-based cognitive stimulation activities to understand which approach better supports cognitive function. The trial involves 307 patients and explores cognitive outcomes, quality of life, and daily living abilities.
Participants are randomly assigned to one of two groups. One group trains using 10 exercises from the Scientific Brain Training PRO software designed to enhance various executive functions. The other group completes 10 general cognitive stimulation games from a specially developed website that focus on overall concentration and visuoperceptual skills but place less demand on executive functions. Both groups train for 8 weeks, five days per week, with each session lasting 60 minutes.
During the study, participants undergo neuropsychological testing at the start, immediately after the 8-week training period, and again three months later to assess executive functions. They also complete questionnaires about quality of life and daily activities at these same time points. Researchers monitor compliance with the training and measure outcomes like working memory, verbal fluency, and fear levels. The study includes safety and follow-up assessments over several months, tracking progress and any changes in cognitive and functional abilities.
CONDITIONS
Brief Title
COMPuter-assisted Self-training to Improve EXecutive Function
Research Team
H
Hanne Christensen, Professor
K
Katrine Sværke, M.Sc. Psych.
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Diagnosis of stroke, cardiac arrest, or Parkinson's disease
Aged 18 years or older
Impaired working memory with 5 symbols or less backwards on the CABPad test
Access to a computer and internet at home
Providing informed consent
Stroke patients included within 6 months post-stroke, confirmed by clinical findings and imaging, with initial stroke severity NIHSS 3 or higher
Cardiac arrest patients included within 6 months post ictus
Parkinson's disease patients with clinical diagnosis and receiving anti-parkinsonian medication
You will not qualify if you...
No informed consent provided
Other neurological or psychiatric diseases expected to affect participation
Unable to participate as judged by the investigator
Stroke patients with massive denial of executive dysfunction or severe aphasia affecting test performance
Parkinson's disease patients diagnosed with PD Dementia according to MDS criteria
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 8 weeks
Participants complete computer-based cognitive training for 8 weeks, 5 times a week for 60 minutes. They are assigned to either specialized cognitive rehabilitation or general cognitive stimulation.
Regular training sessions at home 5 times a week
Follow-up
Duration - 3 months after treatment ends
Participants complete neuropsychological tests and questionnaires to assess executive functions, quality of life, and daily living activities at the end of the intervention and 3 months later.
2 visits (in-person) after intervention: one immediately after and one at 3 months follow-up
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
The COMPEX-trial: computer-based cognitive rehabilitation to improve executive function versus unspecific training in patients after stroke, cardiac arrest or in Parkinson's disease: study protocol for a randomized controlled trial.