Actively Recruiting
Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy
Led by Washington University School of Medicine · Updated on 2026-04-30
80
Participants Needed
1
Research Sites
863 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will explore neurocognitive performance in pediatric brain tumor patients receiving proton beam radiation therapy (PBRT). The investigators goal is to gather baseline neurocognitive testing prior to the completion of the first week of radiation therapy along with follow-up testing 6-12 months after the completion of radiation and serial annual testing thereafter. With these data the investigators plan to evaluate the effects of PBRT on neurocognitive performance as it relates to patients' age at diagnosis, tumor location, and radiation dose. Modeling studies have demonstrated that PBRT could improve neurocognitive outcomes, but there is a paucity of prospectively-collected patient data. The investigators are uniquely positioned to address this important question given the busy pediatric central nervous system (CNS) tumor service, the delivery of proton therapy at the S. Lee Kling Proton Therapy Center at Barnes-Jewish Hospital, and the multi-disciplinary research team with extensive experience into the late effects of therapy as it relates to neurocognition.
CONDITIONS
Official Title
Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary CNS tumor or metastatic disease to the CNS with expected survival over 1 year
- Planning to receive proton beam radiation therapy for CNS tumor or already received PBRT with prior baseline cognitive testing
- Age between 4 and 21 years inclusive
- Life expectancy of at least one year
- No visual impairment that would prevent computer-based testing
- No secondary health conditions impacting cognitive function (e.g., unrelated psychiatric or developmental disabilities)
- Able to understand and willing to sign informed consent or have a legal representative sign
You will not qualify if you...
- Visual impairment that would prevent computer-based testing
- Secondary health conditions that impact cognitive function unrelated to cancer
- Life expectancy less than one year
- Unable or unwilling to provide informed consent or have a legal representative consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
S
Stephanie Perkins, M.D.
CONTACT
L
Lindsey Brunt, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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