Actively Recruiting
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Led by Yale University · Updated on 2026-05-01
200
Participants Needed
2
Research Sites
176 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
B
Burroughs Wellcome
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic psychedelic. The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving serotonergic psychedelics through any clinical trial at Yale University. The main questions it aims to answer are: 1. Do serotonergic psychedelics cause the brain to rely on new information more than previously learned information while under the influence? What about 1 day, 5-14 days, and 4-6 weeks after use? 2. Do serotonergic psychedelics cause long-lasting side-effects in how people perceive (see, hear, feel, etc.) the world and how easily people change their beliefs? 3. How does the brain's electrical activity change after using serotonergic psychedelics? How does the balance between excitation and inhibition change while under their effect? 4. Can changes in how the brain uses information predict who will benefit from a psychedelic and who will have side effects from psychedelics? Researchers will compare with people given placebos to see what changes in brain processing are unique to serotonergic psychedelics. Participants will have the opportunity to do some combination of the following: 1. Online computer assessments consisting of games and questionnaires that probe how participants think. 2. Magnetoencephalography (MEG) or electroencephalography (EEG) with eyes closed and with repeated clicks, images, or sensations delivered. 3. A magnetic resonance imaging (MRI) scan. 4. Semi-structured qualitative interviews about their experience after taking a serotonergic psychedelic recorded via Zoom.
CONDITIONS
Official Title
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participation in an approved clinical protocol at Yale University involving potential administration of serotonergic psychedelics
- No pre-existing psychotic symptoms
You will not qualify if you...
- Current intoxication
- Any neurological, medical, or developmental problems that significantly impair cognition
- History of seizures
- Contraindications for MRI such as metal implants, pacemakers, metal-related injuries, or claustrophobia (if MRI participation is planned)
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Connecticut Mental Health Center
Hamden, Connecticut, United States, 06517
Actively Recruiting
2
West Haven VA Medical Center
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
M
Maximillian S Greenwald, BA
CONTACT
A
Albert R Powers, MD,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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