Actively Recruiting
Led by VA Office of Research and Development · Updated on 2025-07-14
152
Participants Needed
1
Research Sites
N/A
Total Duration
Depression is a common issue among Veterans and can lead to serious difficulties in daily functioning and quality of life. This research aims to evaluate Deprexis, a self-guided internet program designed to reduce depressive symptoms and improve functioning in Veterans with mild to moderate depression. The study seeks to understand Veterans' views on Deprexis and test its effectiveness compared to usual care in a controlled trial setting. Participants will be randomly assigned to either an 8-week course of Deprexis, which includes interactive modules to help manage depression, or continue with their usual treatment. The study will first gather feedback from a smaller group of Veterans to improve the program and then conduct a larger trial to compare outcomes between those using Deprexis and those receiving standard care. Throughout the study, Veterans will complete assessments measuring depression symptoms and functional ability at the start, after 8 weeks, and again 8 weeks later. Researchers will analyze these results to see if Deprexis helps reduce symptoms and improve daily functioning. The study aims to provide accessible, low-cost support for Veterans experiencing depression, potentially helping to reduce long-term disability and suicide risk.
CONDITIONS
A Computerized Depression Intervention in Veterans
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You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) to assess eligibility
Duration - 8 weeks
Participants engage in an 8-week course of Deprexis, a self-guided internet-delivered behavioral intervention for depressive symptoms and related functional impairment.
Participants use the online program independently; assessments occur at baseline and post-treatment
Duration - 8 weeks
Participants complete follow-up assessments 8 weeks after treatment to evaluate lasting effects on depressive symptoms and functioning.
1 follow-up assessment visit (remote or in-person)
Total: 1 location
1
Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX
Waco, Texas, United States, 76711
Actively Recruiting
R
Rahel R Pearson, PhD
J
Joseph F Maher
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Rahel Pearson, Christopher G Beevers, Joseph Mignogna...
https://pubmed.ncbi.nlm.nih.gov/39446432