Actively Recruiting
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children Undergoing Orthopedic, Abdominal, Thoracic, and Plastic Surgeries
Led by American University of Beirut Medical Center · Updated on 2025-03-18
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to investigate how specific genetic variations, particularly the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor 1 (OPRM1) gene and several SNPs in the Catechol-O-methyltransferase (COMT) gene, may influence postoperative pain and other recovery-related outcomes in children aged 8 to 18 undergoing various surgeries including orthopedic, abdominal, thoracic, and plastic procedures. The study focuses on understanding differences in pain sensitivity and opioid response among children due to these genetic factors. This is a prospective observational study involving about 200 children who will be monitored for their postoperative pain scores and other recovery aspects without altering their usual care. Researchers will assess pain levels, sedation, opioid use during and after surgery, the duration of stay in the post-anesthesia care unit (PACU), and occurrences of respiratory depression or nausea and vomiting. Genetic testing will be conducted, but the study does not involve any experimental treatments. Participants will be evaluated during surgery and until discharge from the PACU, approximately 3 hours postoperatively. Data collected include pain scores, sedation levels, opioid requirements, and recovery duration, along with monitoring for side effects like respiratory depression and nausea. The study will use statistical analyses to explore how genetic differences relate to these outcomes, with the goal of improving personalized pain management for children undergoing surgery.
CONDITIONS
Brief Title
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 8 to 18 years
- Undergoing orthopedic, abdominal, thoracic, or plastic surgeries
- Classified as American Society of Anesthesiologists (ASA) class I, II, or III
You will not qualify if you...
- Children with schizoid personality disorders, phobias, or anxiety
- Patients with neuropathic pain requiring surgical treatment
- Children with depressive disorders, atypical bipolar disorder, or suspected substance abuse
- Classified as ASA class IV or higher
- Receiving regional anesthesia, local blocks, epidural, or caudal blocks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 day
Participants undergo genetic testing to evaluate COMT and OPRM1 polymorphisms related to pain perception and opioid response.
1 visit (in-person)
Duration - About 3 hours
Participants are observed for postoperative pain, sedation, opioid use, respiratory depression, nausea and vomiting until discharge from the post-anesthesia care unit (PACU).
Continuous monitoring during PACU stay
Trial Site Locations
Total: 1 location
1
Roland Kaddoum
Beirut, Lebanon
Actively Recruiting
Research Team
R
Roland Kaddoum, MD
T
Thouraya HajAli
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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