Actively Recruiting
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
Led by American University of Beirut Medical Center · Updated on 2025-03-18
200
Participants Needed
1
Research Sites
96 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries. The main question\[s\] it aims to answer \[is\]: Do OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries? Participants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.
CONDITIONS
Official Title
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 8 to 18 years
- Undergoing orthopedic, abdominal, thoracic, or plastic surgeries
- American Society of Anesthesiologists classification ASA I, II, or III
You will not qualify if you...
- Children with schizoid personality disorders, phobias, or anxiety
- Presence of neuropathic pain requiring surgical treatment
- Children with depressive disorders, atypical bipolar disorder, or suspected substance abuse
- American Society of Anesthesiologists classification ASA IV or higher
- Patients receiving regional anesthesia, local blocks, epidural, or caudal blocks
AI-Screening
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Trial Site Locations
Total: 1 location
1
Roland Kaddoum
Beirut, Lebanon
Actively Recruiting
Research Team
R
Roland Kaddoum, MD
CONTACT
T
Thouraya HajAli
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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