Actively Recruiting
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
Led by Hospital for Special Surgery, New York · Updated on 2025-11-20
40
Participants Needed
2
Research Sites
253 weeks
Total Duration
On this page
Sponsors
H
Hospital for Special Surgery, New York
Lead Sponsor
E
Emory University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.
CONDITIONS
Official Title
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 18 to 55 years
- Previous unilateral ACL reconstruction within the last 5 years with failure of the primary ACLR
- Scheduled for revision ACL reconstruction surgery with any graft type
- Able to complete all study procedures and participate in a standardized physical therapy program
You will not qualify if you...
- History of inflammatory arthritis or joint infection
- Prior or current total or sub-total meniscectomy
- Prior or present avascular necrosis of the index knee
- Corticosteroid injection (oral or intra-articular) within 3 months
- Hyaluronic acid or platelet-rich plasma injection within 6 months
- Use of duloxetine, doxycycline, indomethacin, glucosamine, and/or chondroitin ongoing or within 2 months
- Any clinical or laboratory abnormality greater than grade 3 CTCAE that may compromise safety
- Planned knee arthroplasty on the index knee
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Emory Orthopaedics & Spine Center
Atlanta, Georgia, United States, 30097
Actively Recruiting
2
Hospital for Special Surgery
New York, New York, United States, 10021
Actively Recruiting
Research Team
D
Daniel de la Huerta, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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