Effects of Daily SPM Active Supplement on Omega-3 Fatty Acid Derivatives and Well-Being in Adults with Obesity Aged 45 to 60

What this Trial Is About

Researchers are studying the effects of the dietary supplement SPM Active4, which contains omega-3 polyunsaturated fatty acid derivatives, in adults with obesity. The study focuses on whether taking 2 grams daily for 12 weeks increases levels of specific monohydroxylated derivatives 14-HDHA, 17-HDHA, and 18-HEPE that may help reduce chronic inflammation. It also aims to assess changes in self-reported burnout, life satisfaction, and sleep quality in participants aged 45 to 60 with a body mass index BMI between 30 and 40 kgm. Participants will take two soft-gel capsules of SPM Active4 each day for about 12 weeks, with a small window of a few days. Blood samples will be collected after fasting for 12 hours, both before and after the supplementation period, to measure levels of the omega-3 derivatives. Validated surveys evaluating burnout, life satisfaction, and sleep quality will be completed by participants at the start and end of the intervention. Throughout the trial, participants will provide fasting blood samples and complete questionnaires to track changes related to the supplement. Researchers will monitor the blood levels of the targeted fatty acid derivatives and assess participant well-being using validated survey scores. The study is sponsored by the University of North Carolina, Chapel Hill, and participation lasts for the 12-week supplementation period plus assessments at baseline and study completion.

Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.