Study of Combined Kidney and Bladder Transplant in Patients with Chronic Kidney Disease and Bladder Disorders

What this Trial Is About

Researchers are investigating whether it is possible to perform kidney and bladder transplants together in patients who have chronic kidney disease caused by bladder problems or absence of a bladder. This early-phase, single-center study focuses on patients whose bladder issues have not improved with medical treatment and who need surgery to avoid long-term complications. The study includes patients with hostile bladders, defined by specific bladder pressure measurements or bladder muscle disorders, and candidates must be approved by a transplant team. Participants will receive a transplant of a cadaveric donor bladder either at the same time as or after their kidney transplant, instead of the usual method of using intestinal segments for bladder reconstruction. This is a single-group study where all patients receive this combined transplant procedure. The research aims to evaluate the feasibility of this approach and study the long-term function of the transplanted bladder. During the study, participants will be closely monitored for how well the transplanted organs work and for any serious side effects over the course of up to four years. The medical team will conduct evaluations including urinary function assessments and follow-up visits to understand the outcomes and safety of the combined transplant. The total study period includes careful long-term observation to assess the success and any risks associated with the procedure.

Concomitant Renal and Urinary Bladder Allograft Transplantation