Actively Recruiting
Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke
Led by Kafrelsheikh University · Updated on 2026-04-23
600
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Along with the current clinical trial, the impact of adding atorvastatin or rosuvastatin in the first 24 hours on the clinical outcomes of first-ever small vessel stroke patients treated with clopidogrel and aspirin assessed through NIHSS, mRS, and possible adverse effects.
CONDITIONS
Official Title
Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 18 to 75 years
- First-ever moderate or small vessel stroke
- Patients not eligible for rt-PA treatment
You will not qualify if you...
- Rapidly resolving stroke symptoms before imaging
- History of persistent or recurrent central nervous system diseases such as epilepsy, meningioma, multiple sclerosis, or head trauma with residual neurological deficit
- Clinical seizures at stroke onset
- Symptoms of major organ failure or active cancer
- Acute myocardial infarction within the previous six weeks
- Use of warfarin, regular ticagrelor in the week before admission, or chemotherapy within the previous year
- Active peptic ulcers, recent gastrointestinal surgery, or bleeding history within the last year
- Major surgery within the last three months
- Known allergy to study drugs
- INR above 1.4 or prothrombin time over 18 seconds
- Blood glucose below 50 mg/dL or above 400 mg/dL
- Blood pressure below 90/60 mmHg or above 185/110 mmHg on admission
- Platelet count below 100,000
- Pregnancy or lactation
- Stroke due to venous thrombosis or following cardiac arrest or severe low blood pressure
- Regular use of drugs affecting clopidogrel metabolism such as ketoconazole, dihydropyridine calcium channel blockers, or rifampin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt, 33511
Actively Recruiting
Research Team
M
mohamed G. Zeinhom, MD
CONTACT
S
sherihan R. ahmed, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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