Actively Recruiting
Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV
Led by Centre Hospitalier Universitaire de la Réunion · Updated on 2025-12-11
398
Participants Needed
2
Research Sites
57 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Anal canal cancers are on the increase in France, with around 2,000 new cases per year. These lesions can be detected by directed biopsies or smear tests. The incidence rate of anal cancer is 30 times higher in people living with HIV than in the general population. According to a recent study, the risk of anal cancer is highest in this population, but is also high in heterosexual men over 30 and women over 30. However, the proposal of a proctological examination in this population is not systematic. In France, there is no HPV screening for people living with HIV, but there is a recommendation for proctology consultation in certain cases, notably for men who have sex with men (MSM) or for women with vaginal cervical lesions. Several oncogenic HPV serotypes have been identified in the genesis of anal cancer. The serotype identified as the most carcinogenic is HPV-16 (89%). This study will look at anal HPV screening in people over 30 living with HIV, thus including a population for which no screening is currently offered (heterosexual men living with HIV and women living with HIV without vaginal cervical lesions), and will assess the concordance and acceptability of self-screening versus screening by a healthcare professional as part of a comprehensive anal cancer screening strategy in this population.
CONDITIONS
Official Title
Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Living with HIV
- Aged 30 years or older
- Resident of Reunion Island and followed at the University Hospital of Reunion Island
- Able to perform anal self-sampling
- Able to answer a questionnaire
- Affiliated with or benefiting from a social security scheme
- Provided free, informed, and signed consent
You will not qualify if you...
- Had an anal swab less than 7 days ago
- Known current diagnosis of anal cancer
- Deprived of liberty by judicial or administrative decision
- Minor or under legal protection such as guardianship or curatorship
AI-Screening
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Trial Site Locations
Total: 2 locations
1
CHU de la Réunion Recherche Clinique
Saint-Denis, Reunion, 97400
Not Yet Recruiting
2
CHU de la Réunion Recherche Clinique
Saint-Pierre, Reunion, 97448
Actively Recruiting
Research Team
L
Lucie AUZANNEAU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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