Study Comparing Self-Collection and Professional Collection for HPV Screening in People Aged 30 and Over Living With HIV on Reunion Island

What this Trial Is About

Anal canal cancers are becoming more common in France, especially among people living with HIV, who face a risk 30 times higher than the general population. This study focuses on people living with HIV aged 30 or older, including heterosexual men and women without vaginal cervical lesions, to evaluate anal HPV screening methods. The goal is to assess the agreement and acceptance of self-screening compared to screening performed by healthcare professionals as part of a strategy to detect anal cancer risk. Participants will be randomly assigned to one of two groups one group will perform anal self-swabbing first followed by a healthcare professional swabbing, and the other group will have the professional swabbing first followed by self-swabbing. Both methods involve collecting anal swabs to test for HPV, particularly the HPV-16 genotype known for its cancer risk. The study compares the results from the two sampling methods and gathers information on participant preference, satisfaction, and any side effects like discomfort or bleeding. During the study, participants will provide samples and answer questionnaires about their experience. Researchers will evaluate how well the self-sampling matches professional sampling and measure the prevalence of anal HPV infections. The study will also monitor any adverse events and assess overall acceptability of both methods. Participation includes follow-up within 7 days after sampling to gather results and feedback, with the entire process designed to improve anal cancer screening in this high-risk group.

Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV