Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits in Adenocarcinoma of the Colon, Sigmoid, or Rectum

What this Trial Is About

Researchers are studying patients with suspected primary adenocarcinoma of the colon, sigmoid, or rectum who are scheduled for surgery. The goal is to see if using imaging mapping techniques before surgery can improve how well imaging and pathology agree in detecting tumour deposits. This study is a prospective, interventional, multi-center trial aiming to assess if additional radiological and pathological assessments can provide supplementary diagnostic information that might influence treatment and prognosis discussions. The study involves using MRI mapping to identify lymph nodes and tumour deposits on pre-operative scans. Radiologists will mark areas where extranodal disease is detected, and this map will be shared with pathologists before they process the surgical specimen. This approach guides the pathological sampling of tumour deposits in the mesorectum, which may lead to better pathological staging and impact treatment decisions. Patients will receive standard care and follow-up at their local hospitals. Participants will be followed for up to five years to monitor outcomes such as disease-free survival, overall survival, and time to local recurrence. Assessments include comparing imaging and pathology diagnoses of tumour deposits, evaluating features of the primary tumour and lymph nodes, and measuring agreement between local and central radiologists and pathologists. The primary outcome is to determine if imaging mapping increases detection of tumour deposits on pathology within two years. Safety monitoring and long-term follow-up are included as part of the study.

Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits