Study of Combined Laparoscopic Hysterectomy and Weight Loss Surgery for Obese Women with Early Endometrial Cancer or Pre-Cancer

What this Trial Is About

This research aims to evaluate a faster referral process for obese women diagnosed with early-stage endometrial cancer or endometrial intraepithelial neoplasia EIN to receive combined weight loss surgery and hysterectomy. The study focuses on how to safely schedule and perform these surgeries together without delaying cancer treatment, as obesity is a major risk factor for endometrial cancer and related health problems like heart disease and diabetes. This is a feasibility study conducted at Brigham and Womens Hospital involving about 30 participants. Participants will be referred from their gynecologic oncologist to the Center for Metabolic and Bariatric Surgery, where they will meet with a bariatric surgeon, nutritionist, and psychologist to complete the pre-surgery approval process. The combined laparoscopic hysterectomy and weight loss surgery will be scheduled on the same day within 8 weeks of the first gynecologic oncology visit for cancer patients, or within 12 weeks for those with EIN. After surgery, patients will have follow-up visits with the surgical team and support specialists. During the study, researchers will monitor the timing of appointments and surgeries, safety and complications from the combined procedures, time spent under anesthesia and in the operating room, and weight loss at 6 months and 1 year post-surgery. They will also assess changes in lab tests related to obesity-related conditions and quality of life using a health survey. Total participation includes the surgery and postoperative follow-up visits to track recovery and outcomes.

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia