Actively Recruiting

Phase Not Applicable
Age: 18Years +
MALE
NCT06065436

Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease

Led by Mayo Clinic · Updated on 2026-01-07

60

Participants Needed

1

Research Sites

154 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this research is to determine whether or not low-intensity shockwave therapy (LiSWT) with Xiaflex treatment will result in greater improvements to the curvature of the penis.

CONDITIONS

Official Title

Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease

Who Can Participate

Age: 18Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with Peyronie's Disease
  • Presence of palpable penile plaque
  • Penile curvature located dorsally, laterally, or dorsolaterally
  • Penile curvature greater than 30 degrees and less than 90 degrees measured by goniometer
  • Non-calcified plaque or grade 1 calcification (stippling without shadowing) per penile duplex Doppler ultrasound
  • Stable Peyronie's Disease symptoms: symptom duration over 6 months or stable symptoms over more than 3 months
Not Eligible

You will not qualify if you...

  • Prior intralesional injections or surgery for Peyronie's Disease
  • Severe baseline penile pain
  • Moderate or severe erectile dysfunction based on IIEF-EF domain
  • Previous low intensity shockwave therapy for sexual dysfunction
  • Ventral (downward) or ventrolateral penile curvature
  • Moderate or severe (grade 2 or 3) plaque calcification per penile duplex Doppler ultrasound
  • Inability to achieve satisfactory erection rigidity at baseline curvature assessment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Mayo Clinic Minnesota

Rochester, Minnesota, United States, 55905

Actively Recruiting

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Research Team

W

Wyatt H Anians, CCRP

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease | DecenTrialz