Actively Recruiting
Concurrent Neoadjuvant Chemo/Endocrine Therapy in HER2+ Breast Cancer
Led by Legacy Health System · Updated on 2026-05-01
30
Participants Needed
4
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The usual approach to care for hormone receptor positive, HER2 positive breast cancer is chemotherapy and HER2 targeted therapy followed by endocrine therapy and surgery. The purpose of this Research Study is to see if taking endocrine therapy with the chemotherapy and HER2 directed therapy increases patients response to therapy at the time of surgery
CONDITIONS
Official Title
Concurrent Neoadjuvant Chemo/Endocrine Therapy in HER2+ Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years of age with newly diagnosed, previously untreated, hormone receptor positive, HER2 positive breast cancer
- Endocrine therapy may be started within 28 days prior to trial enrollment and must begin before the second cycle of chemotherapy/HER2 therapy
- Choice of endocrine therapy decided by the treating or enrolling physician
- Anatomic stage IIA to IIIC breast cancer planning at least 4 cycles of TCHP chemotherapy
- Patients must have Luminal A, Luminal B, or HER2 enriched subtype based on MammaPrint/BluePrint testing on the initial biopsy
You will not qualify if you...
- Children under 18 years of age, pregnant women, prisoners, and decisionally impaired adults
- Patients with any non-breast cancer diagnosed within the past 2 years
- Patients with breast cancer diagnosed within the past 5 years
- Patients with recurrent breast cancer
- Patients with stage IV (advanced) breast cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Legacy Mount Hood Medical Center
Gresham, Oregon, United States, 97030
Actively Recruiting
2
Legacy Good Samaritan Medical Center
Portland, Oregon, United States, 97210
Actively Recruiting
3
Legacy Meridian Park Medical Center
Tualatin, Oregon, United States, 97062
Actively Recruiting
4
Legacy Salmon Creek Medical Center
Vancouver, Washington, United States, 98686
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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