Actively Recruiting
Concurrent TMS-fMRI
Led by Jing Jiang · Updated on 2026-03-12
97
Participants Needed
1
Research Sites
249 weeks
Total Duration
On this page
Sponsors
J
Jing Jiang
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half male and half female participants aged 18-65 will be recruited. The main questions it aims to answer are: 1. Is the acute/transient effect induced by single-pulse TMS related to the long-term modulatory effect induced by repetitive TMS (rTMS)? 2. Do any of these effects predict negative affect symptoms, such as depression? Participants will: 1. Complete several tests to assess their cognitive abilities and emotional states 2. Undergo several brain scans, including resting-state fMRI, structural MRI, diffusion tensor imaging (DTI), and task fMRI 3. Have two different types of TMS sequences, single-pulse and repetitive pulses, administered to specific brain regions while undergoing fMRI
CONDITIONS
Official Title
Concurrent TMS-fMRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For patients: diagnosis of major depressive disorder
- Aged between 18 and 65 years
- Able to understand and give consent for research participation
- English-speaking
- For healthy controls: no lifetime psychiatric diagnosis or treatment
- Scores lower than 4 on Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7)
- Aged between 18 and 65 years
- Able to understand and give consent for research participation
- English-speaking
You will not qualify if you...
- Age younger than 18 or older than 65 years
- History of epilepsy or seizure disorder
- Implanted ferromagnetic equipment in face or skull near stimulation target
- Implanted device not compatible with MRI such as pacemaker, coronary stent, defibrillator, or neurostimulation device
- Presence of metal in body including bullets, shrapnel, or metal slivers
- Claustrophobia
- Uncontrolled high blood pressure
- Blood circulation problems
- Use of opiate, antihypertensive, or medications interfering with blood flow affecting fMRI
- Significant heart disease including atrial fibrillation
- Pregnancy in female participants
- Prior exposure to deep brain stimulation, repetitive TMS, or transcranial direct current stimulation therapies
- History of neurological or cardiovascular disorders, brain surgery, radiation treatment, brain hemorrhage or tumor, stroke, or diabetes
- Significant traumatic brain injury with loss of consciousness, amnesia, neurological findings, or penetrating brain injury
- Refusal to abstain from illicit drug use during the study
- Refusal to abstain from alcohol within 24 hours of scans
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Carver College of Medicine
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
J
Jing Jiang, PHD
CONTACT
E
Emily Gittle, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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