Docetaxel

Researchers are evaluating adjuvant chemotherapy for patients with stage III gastric cancer who have undergone D2 gastrectomy and achieved R0 resection. This phase 3, open-label, randomized study compares the effects of oxaliplatin plus S-1 versus docetaxel plus S-1 on disease-free survival. The study aims to provide direct comparison of these two chemotherapy regimens, focusing on their safety profiles, treatment duration, and patient adherence. Participants are randomly assigned to one of two treatment groups. The first group receives eight 3-week cycles of intravenous oxaliplatin with oral S-1 doses adjusted by body surface area. The second group receives oral S-1 for the first cycle, followed by six cycles of intravenous docetaxel plus oral S-1, and then continues oral S-1 for up to one year. The treatments are given after surgery, and the study includes follow-up for five years. During the study, participants undergo monitoring for disease recurrence and overall survival, along with safety assessments over approximately six months of treatment. The main outcome measured is the 3-year disease-free survival rate, with secondary outcomes including 5-year overall survival, safety profiles, and recurrence sites. The study will track patients closely with regular evaluations throughout the treatment and follow-up periods.

This research aims to understand treatment outcomes in children and adolescents with relapsed or refractory germ cell tumors who receive specific high-dose chemotherapy regimens and stem cell transplantation. The focus is on estimating overall survival and progression-free survival rates in patients undergoing tandem autologous stem cell transplants using gemcitabine, docetaxel, melphalan, and carboplatin GemDMC followed by a second transplant with carboplatin and etoposide CE. Participants undergo two consecutive high-dose chemotherapy courses with stem cell transplants. The first course includes gemcitabine, docetaxel, melphalan, and carboplatin administered intravenously over several days followed by stem cell infusion. The second course uses carboplatin and etoposide, also given intravenously, followed by a second stem cell infusion. This observational study follows patients receiving these treatments to collect data on their outcomes. During the study, researchers monitor safety and any adverse events for an average of one year after treatment completion. Information is collected on treatment responses and patient survival to better understand the effects of this approach. The study includes pediatric and adolescent patients treated with this regimen, including those who previously received it, to gather comprehensive outcome data over the course of participation.