Legg-Calve-Perthes Disease

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or WeilHohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing 10-15 kg during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are evaluating the effect of a student-led multimodal prehabilitation service called BoneFit for people preparing for total hip or knee replacement surgery. The study aims to improve physical and mental health, quality of life, and reduce hospital stay length, complications, and readmission rates for patients undergoing orthopedic surgery in the Hull region. This pilot feasibility study will compare BoneFit to usual care, as no prehabilitation service is currently offered locally. Participants in the BoneFit intervention group will receive a personalized care plan that includes exercise, nutrition, and psychological support tailored to their needs during the 8 weeks before surgery. A control group will receive usual care without intervention. The groups will be compared to assess the impact of the prehabilitation service. During the study, participants will undergo baseline tests and will be invited to repeat these assessments 3 months after surgery. Researchers will monitor recruitment, attendance, and acceptability over several years. They will also measure physical fitness, hospital length of stay, readmission rates, overall quality of life, and specific pain and function related to the knee or hip. The study will last up to 3 years, with ongoing follow-up assessments to evaluate outcomes.

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis CACP syndrome is a rare inherited disorder caused by mutations in the PRG4 gene. It is characterized by the combination of camptodactyly bent fingers or toes, joint problems without inflammation, and deformity of the hip bone, sometimes also involving heart and lung issues. The syndrome shows variable symptoms and may be underdiagnosed due to its rarity and resemblance to juvenile arthritis. This European multicenter study aims to collect detailed clinical, genetic, and therapeutic data to better understand the diseases characteristics and progression in children diagnosed with CACP syndrome. Participants are children diagnosed with CACP syndrome confirmed by genetic testing who were diagnosed between 2005 and early 2026. The study involves regular clinical visits approximately every six months to monitor symptoms, joint function, and possible complications like pericarditis. Imaging and lab tests are done every 1 to 2 years or as needed. No specific drug treatment is available, and the study focuses on observing the disease course, treatment approaches, and genotype-phenotype relationships over a 10-year period. Throughout the study, researchers will collect epidemiological and clinical information, including disease incidence, geographic and ethnic distribution, symptom progression, and treatment outcomes. Patient disability, pain levels, and well-being will be tracked using questionnaires. The study will also document any misdiagnoses before confirmation of CACP. Monitoring adverse events related to treatments used will be included. This long-term observation will help improve understanding and management of CACP syndrome in affected children.

This observational study is focused on collecting data about the performance of CERAMENT BONE VOID FILLER, a synthetic biphasic bone graft substitute, when used in typical medical practice for orthopedic disorders. The study is sponsored by BONESUPPORT AB and aims to gather information on device performance and patient outcomes to understand its use in real-world settings. Participants will receive CERAMENT BVF as part of their treatment at approved healthcare centers following the products instructions for use. Data collection includes monitoring unexpected device performance, complaints, adverse events, and serious adverse events during surgery and continuing up to 18 months after treatment. Radiological assessments, pain scores, and quality of life evaluations will be conducted at intervals throughout the study. During the study, participants will undergo scheduled reviews at 6, 12, and 18 months to assess device-related outcomes and healing progress using imaging and questionnaires. Researchers will track safety events and gather patient-reported outcomes such as pain levels and quality of life. Participation involves following up with healthcare providers over this period to provide ongoing data for comprehensive evaluation of the devices performance.

This research evaluates the clinical and radiological outcomes in patients who have undergone total ankle replacement for advanced ankle osteoarthritis. The study aims to assess results achieved by surgeons who did not originally design the implant, addressing potential bias seen in prior studies where designers performed the surgeries. The goal is to compare these outcomes with those of ankle arthrodesis, considering improvements in surgical techniques and ankle biomechanics knowledge. Participants in the study have received total ankle arthroplasty using a third-generation ankle replacement device. Clinical assessments are performed before and after surgery, with a minimum follow-up of 12 months. These include the American Orthopedic Foot and Ankle AOFAS score, the Foot Function Index, and the visual analogue scale VAS for pain. Weightbearing ankle X-rays are taken before surgery and at the final follow-up, with independent review by an orthopedic surgeon. During the study, participants complete scheduled follow-up evaluations, questionnaires, and radiographic exams. Researchers measure implant survivorship over 10 years along with various ankle joint angles and functional scores. The study monitors clinical progress, radiological changes, and foot function to evaluate long-term outcomes of the ankle replacement procedure.

Proximal humerus fractures can seriously affect elderly patients by limiting shoulder movement and causing pain, which impacts daily activities. This trial evaluates the timing of rehabilitation after reverse total shoulder arthroplasty rTSA in patients with these fractures, focusing on whether starting physical therapy early or later affects recovery and post-surgery complications. The study aims to identify safer, more effective rehabilitation protocols for this specific trauma patient group. Participants will be randomly assigned to start physical therapy either 2 weeks or 6 weeks after their rTSA surgery. Both groups will follow their assigned rehabilitation schedule, and researchers will compare outcomes such as shoulder range of motion and patient-reported shoulder function. The study includes in-person clinic visits and X-rays at 6 weeks, 3 months, and 6 months post-surgery to track progress and complications. Throughout the study, participants will attend scheduled visits for assessments of shoulder movement using a goniometer and complete outcome questionnaires. Researchers will also review medical records to monitor postoperative complications. The total follow-up lasts 6 months, providing detailed data on how rehabilitation timing influences recovery, patient function, and safety after rTSA for proximal humerus fractures.

Researchers are evaluating the effect of a podcast about constipation on patients undergoing planned orthopedic surgeries such as knee, hip, shoulder, and back operations. This randomized controlled trial aims to see if the podcast can reduce the number of patients experiencing constipation before and after surgery. The study includes adults 18 years or older who can use digital devices and do not have certain gastrointestinal conditions or severe hearing or cognitive impairments. Participants will be randomly assigned to either a control group or an intervention group. Both groups receive standard preoperative information, but the intervention group also gets access to a 30-minute podcast featuring expert explanations and patient experiences related to constipation around surgery. The podcast is accessible throughout the study period. Data will be collected through online questionnaires at four points after the preoperative consultation, shortly before surgery, one week after surgery, and four weeks after surgery. During the study, participants will complete questionnaires assessing constipation using the ROME IV Diagnostic Criteria and quality of life related to constipation via the PAC-QOL tool. Additional information will be gathered about laxative use, educational and living situations, and healthcare contacts from patient records. The researchers will monitor hospitalizations, outpatient visits, and general practitioner contacts up to six months after surgery to evaluate the overall impact. Participation lasts from pre-surgery consultation through four weeks after surgery, with some data extending to six months post-surgery.

Researchers are conducting an international post-market clinical follow-up study to collect safety and performance data on commercially available Pyrocarbon hand and wrist implants. The study aims to gather information on clinical complications and outcomes related to these implants in real-world use, satisfying post-market surveillance and regulatory requirements. This multicenter observational study collects data before surgery, during surgery, and at multiple follow-up points approximately 2 years, 5 years, and 10 years after the procedure. It focuses on patients treated with sponsor-approved Pyrocarbon implants for hand or wrist arthroplasty, including both primary and revision surgeries. Participants will be assessed using various clinical measurements such as the QuickDASH score, Patient Satisfaction scores, implant survivorship, and safety evaluations over a period up to 10 years. Data collection includes clinical assessments of strength, mobility, and wrist function changes from baseline. This long-term follow-up helps monitor implant performance and participant well-being.

Researchers are studying patients with orthopedic disorders to enhance the quality of care they receive at St Luc Hospital in Brussels. This study aims to evaluate the effects of different orthopedic treatments on bone and muscle structure, mobility, strength, stiffness, and patients ability to perform daily activities and participate in social, work, and cultural life. The study uses the International Classification of Functioning, Disability and Health ICF model to provide a comprehensive assessment rarely applied to musculoskeletal impairments. Participants with muscular-skeletal impairments such as arthrosis or bone and muscle injuries will receive various treatments selected by their orthopedists, including surgical options or conservative approaches like plaster, braces, or physiotherapy. The study compares these treatments effects on patients function and quality of life, while also collecting precise surgical data to assess and improve surgical accuracy and care quality. During the study, patients will undergo clinical assessments, questionnaires, and laboratory movement analyses tailored to their treatment goals. They will continue their usual clinical follow-up with imaging and functional tests, supplemented by quantified movement evaluations and satisfaction surveys. Researchers will measure outcomes related to patients activity levels, impairments, and participation over six months to better understand treatment impacts and enhance orthopedic care.

Researchers are evaluating whether an additional intravenous treatment with zoledronic acid can improve tendon healing after arthroscopic surgery for chronic rotator cuff tears. This phase II, prospective, placebo-controlled study focuses on adults aged 50 to 70 years who have verified rotator cuff tears. The study is supported by the General Accident Insurance Institution AUVA and aims to prove the benefit of zoledronic acid compared to no additional therapy. Participants are randomly assigned to receive either a single intravenous infusion of 5 mg zoledronic acid Aclasta or a placebo infusion of physiological saline solution 100 ml. Both treatments are given once, and the study is double-blinded. The primary treatment period includes the surgery and study infusion, followed by a standardized physiotherapy program using a shoulder abduction pad for four weeks after surgery. Throughout the study, tendon healing is monitored primarily through magnetic resonance imaging over an eight-year period to assess rotator cuff tendon integrity. Participants will undergo regular evaluations, including imaging and clinical assessments, to track healing progress. The study also involves long-term follow-up to observe the outcomes of the adjuvant therapy on tendon repair after the surgical procedure.