Tendon Injury

Researchers are evaluating the quality of 3D hand modelization using the EOS imaging system compared to the standard computed tomography (CT) scans. The study focuses on patients who require CT imaging of the hand or wrist to assess the accuracy and potential benefits of the EOS imaging device. Participants will undergo EOS hand imaging, and these images will be compared directly with their standard CT images. The primary goal is to collect and analyze data from both imaging methods at 60 days to determine how well the EOS system performs in creating 3D models of the hand. During the study, participants will have imaging procedures and data collection focused on the hand or wrist area. Researchers will monitor and compare the imaging outcomes from both EOS and CT methods. The total participation duration includes data evaluation at day 60, with no additional treatment or long-term follow-up specified.

Calcific tendinitis of the shoulder is a common condition involving calcium deposits in the rotator cuff tendons, often causing pain and functional issues. While many classification systems exist, they do not directly guide treatment or prognosis. This study aims to create a new, practical classification based on MRI localization of the deposits, and to explore how this classification relates to the treatments patients receive. The study reviews MRI scans and clinical records from patients treated for calcific tendinitis between 2004 and 2025. Patients are categorized into five groups according to where the calcium deposits are located on MRI: outside the tendon, inside near the joint side, inside near the bursal side, completely within the tendon, or extending into the bone. Treatments include conservative non-surgical methods like pain relief and rest, or surgical interventions such as removal of the deposit and tendon repair techniques. Participants' medical records, operative notes, and treatment details are examined to see how treatment relates to the new classification. The main outcome measured is the change in shoulder function and pain scores from before treatment to 12 months after surgery. This observational study involves reviewing existing patient data to understand the link between deposit location and treatment outcomes over time.

Partial-thickness rotator cuff tear is a common shoulder condition where tears involve 50% or less of the tendon thickness. This trial evaluates the safety and effectiveness of an investigational treatment called TPX-115, which consists of allogeneic fibroblasts injected into the tendon. The study aims to improve tendon repair beyond standard conservative treatments by measuring shoulder function and pain scores over time. Participants are randomly assigned to receive either TPX-115 or a placebo injection guided by ultrasound directly into the tendon. The study is double-blinded, meaning neither participants nor researchers know which treatment is given. Assessments occur at 4, 12, 24, and 52 weeks after injection, with structural evaluations using MRI at 24 and 52 weeks to monitor tendon changes. During the study, participants will complete various shoulder function tests including the Constant Score, pain assessments using Visual Analogue Scale, and other shoulder-specific questionnaires. Range of motion and MRI scans will also be performed to observe physical and structural changes. The primary outcome is the change in Constant Score at 24 weeks, with ongoing safety and efficacy monitoring through one year of follow-up.

Musculoskeletal disorders and injuries cause significant disability worldwide, affecting people of all ages and leading to pain, limited mobility, and reduced quality of life. This ongoing open-label, single-arm phase I/IIa study is evaluating the safety of a human allogeneic bone marrow-derived mesenchymal stromal cell product called StromaForte in patients with musculoskeletal injuries and/or degeneration. The study aims to assess safety and changes in pain over one year after treatment with these stem cells. Participants receive 50 million StromaForte cells locally injected under ultrasound guidance at the injury or degeneration site, combined with or without 100 million cells given intravenously over about 30 minutes. If local injection is not possible, only the systemic intravenous treatment is given. Additional doses may be administered with specified minimum intervals between local and systemic doses. Four subgroups based on connective tissue injury or degeneration type are included. During the study, patients are monitored for adverse events up to one year after treatment. Researchers assess pain levels in each injured or degenerated area, quality of life measures using questionnaires, and changes in pain between treatment subgroups. Follow-up can be face-to-face or remote. This comprehensive evaluation will provide data on safety and patient-reported outcomes following StromaForte administration for musculoskeletal conditions.

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are evaluating the feasibility of a randomized trial comparing perioperative single-shot adductor canal block (ACB) with standard general anesthesia without regional block in children and adolescents aged 10 to 18 undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The study aims to determine if ACB improves quality of recovery as measured by the Quality of Recovery-15 questionnaire at several postoperative time points. Secondary questions include whether ACB reduces opioid use, shortens post-anesthetic care unit stay, improves pain scores, and increases patient satisfaction. Participants will be randomly assigned to receive either a single-shot ACB with ropivacaine and dexmedetomidine after induction of general anesthesia or no nerve block, with all other care standardized between groups. The nerve block is performed under ultrasound guidance. Patients in the non-block group will have a dressing placed to maintain blinding. Follow-up visits occur at postoperative days 2, 14, and 42. During the study, participants and caregivers will complete the Quality of Recovery-15 questionnaire and pain rating scales on the day of surgery and at follow-up calls or clinic visits. Satisfaction ratings will be collected at postoperative day 42 using a 5-item scale. Researchers will also monitor opioid consumption, post-anesthetic care unit time, and any hospital admissions until day 42. Enrollment feasibility will be assessed based on recruitment rates over a 12-month period.

This research aims to evaluate the therapeutic effectiveness of using an acellular dermal matrix derived from human skin combined with autologous orthobiologics for patients with large to massive rotator cuff tears. The study focuses on patients with tears involving the supraspinatus and infraspinatus tendons, addressing a significant surgical challenge. The trial is sponsored by Istituto Ortopedico Rizzoli and involves a randomized, double-blind design to compare treatment methods. Participants will be randomly assigned to one of two groups: one group will receive a suture-bridge surgical repair augmented with the acellular dermal matrix alone, while the other group will receive the same surgical technique combined with orthobiologic treatments, including humeral bone marrow concentrate and subacromial bursa tissue. The orthobiologics are harvested and prepared during surgery using an automatic concentrating system. Both treatments use standard arthroscopic procedures with dedicated sutures and anchors. Throughout the study, participants will undergo pre-operative magnetic resonance imaging and complete outcome assessments. Researchers will monitor the re-tear rate of the rotator cuff at 12 months after surgery as the primary outcome. Secondary outcomes include cell yield and subacromial bursa assessments at baseline. The trial requires participants to be able to understand and complete outcome scores and involves follow-up to evaluate the healing and effectiveness of the treatments over time.

Residual limping due to gluteus medius insufficiency after total hip replacement is a serious complication without effective treatment. This study aims to compare surgical reconstruction of the gluteus medius using an Achilles tendon allograft with non-surgical physiotherapy treatment. The hypothesis is that surgery followed by physiotherapy will improve hip function and reduce limping more than physiotherapy alone. Participants are randomly assigned to one of two groups. One group undergoes surgical reconstruction where an Achilles tendon allograft with a calcaneus block is fixed to the greater trochanter and tensioned through the gluteus medius muscle, followed by partial weight bearing for 2 months and 10 months of physiotherapy. The other group receives only physiotherapy for 12 months without surgery. Throughout the study, participants will be assessed at 12 months using the Oxford Hip Score to measure hip function. Additional evaluations include Trendelenburg's sign, hip abduction strength, activity levels, quality of life indexes, and monitoring of any adverse events. The total study duration for each participant is 12 months, with close observation of treatment outcomes and safety.

Researchers are investigating whether using a 10% benzoyl peroxide (BPO) acne cleanser before arthroscopic rotator cuff repair surgery can reduce contamination by Cutibacterium acnes, a common bacteria that can remain after standard sterilization. Although prior studies showed the bacteria can persist in up to 30% of cases despite cleaning, evidence specifically for rotator cuff surgery is limited. This study aims to provide clear guidance on improving preoperative skin preparation for this type of shoulder surgery. Participants will be randomly assigned to one of two groups. The control group will cleanse the surgical area with soap or body wash following current routine practices. The experimental group will receive a 10% BPO acne cleanser and instructions to use it on the shoulder and surrounding skin during bathing the day before surgery. After surgical disinfection, skin samples and segments of surgical sutures will be collected for bacterial culture to compare contamination rates between groups. During the study, patients will follow preoperative skin cleansing instructions according to their assigned group. Researchers will collect skin and suture samples right after surgery to assess bacterial presence. The primary measurement is the bacterial culture result from sutures immediately after surgery. This prospective randomized design will help determine if BPO cleansing effectively lowers contamination and may influence future surgical preparation practices. Participation lasts through surgery and immediate postoperative sampling.

Researchers are investigating the role of acupuncture in managing pain and improving outcomes after total knee replacement surgery (TKA) for patients with primary osteoarthritis. This study aims to assess whether acupuncture can help control acute pain, prevent chronic pain, improve joint function, and increase patient satisfaction. The research also examines how acupuncture influences inflammation by measuring specific biomarkers, which may relate to recovery and long-term joint stiffness. Participants will receive standard anesthesiology care including sedation, regional nerve blocks, and pain medications. They will be randomly assigned to either a standard treatment group or an acupuncture group, which receives additional acupuncture and auriculotherapy sessions before and after surgery. The acupuncture treatment targets specific body and ear points over multiple sessions during the first three days post-surgery. Throughout the study, participants will be monitored regularly for pain levels, medication use, vital signs, joint mobility, and rehabilitation progress. Blood samples will be taken before surgery and at set intervals afterward to measure inflammation markers. Patient-reported outcomes and satisfaction will be collected up to one year post-surgery. Evaluations will be done in person or by phone if necessary, with the entire follow-up extending through one year after the operation.