Actively Recruiting
Conditioned Pain Modulation in Patients With Hemophilia
Led by Investigación en Hemofilia y Fisioterapia · Updated on 2024-05-24
51
Participants Needed
1
Research Sites
7 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Introduction: Hemophilic arthropathy is characterized by functional alterations, disabling physical sequelae, and chronic pain. Conditioned pain modulation describes the net effect of endogenous pathways that enhance or diminish the effects of afferent noxious stimuli. Objectives: To describe conditioned pain modulation in patients with hemophilia and identify the best predictive model of conditioned pain modulation in these patients Methods: Cross-sectional cohort study. 51 patients with hemophilic arthropathy will be recruited in 3 regions of Spain. The main study variable will be the conditional pain modulation (Conditioned Pain Modulation Index, using an ischemic technique of the arm using the pain pressure threshold as a test stimulus), with age being the dependent variable. The secondary variables, estimated as modifying or confounding variables, will be kinesiophobia (Tampa Scale for Kinesiophobia), catastrophizing (Pain Catstrophizing Scale), trait and state anxiety (State-Trait Anxiety Inventory) and the main clinical, anthropometric, and sociodemographic. Expected results: Identify the degree of modulation conditioned by pain in patients with hemophilic arthropathy. Identify the best predictive model for conditioned pain modulation in these patients based on the study variables
CONDITIONS
Official Title
Conditioned Pain Modulation in Patients With Hemophilia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with hemophilia A or B.
- Patients over 18 years of age.
- Persons with a medical diagnosis of bilateral hemophilic ankle arthropathy.
- Patients with clinical assessment by Hemophilia Joint Health Score (>4 points).
- Persons with hemophilia on prophylactic treatment with FVIII / FIX coagulation concentrates or monoclonal antibodies.
- Have signed the informed consent document.
You will not qualify if you...
- Patients with neurological or cognitive alterations that prevent the comprehension of the questionnaires and physical tests.
- Patients who have had an ankle hemarthrosis in the 6 months prior to the start of the study.
- Patients who have taken analgesic or anti-inflammatory drugs in the 30 days prior to the study.
- Patients who are undergoing an intervention (physiotherapeutic or orthopedic) at the time of the study.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Oviedo
Oviedo, Principality of Asturias, Spain, 33006
Actively Recruiting
Research Team
R
Rubén Cuesta-Barriuso, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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