Actively Recruiting
Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
Led by Brooke Army Medical Center · Updated on 2025-04-23
57
Participants Needed
1
Research Sites
40 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or inhibition of the ascending pain pathway. In those with impaired descending pain pathway function, the response to CPM testing is pro-nociceptive, indicating that the body is unable to inhibit the pain signal, or may even amplify it. There is literature that supports the presence of impaired CPM, and therefore impaired descending pain pathway function, in numerus chronic pain conditions, including low back pain. Impaired descending pain pathway function may be contributing to this chronic pain presentation. This study will give us information on whether a typical physical therapy plan of care is able to improve impaired CPM, and if CPM values are predictive of improvement in physical therapy.
CONDITIONS
Official Title
Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eligible for DEERS
- Able to speak English
- Age between 18 and 64 years
- Baseline Oswestry Disability Index (ODI) score of 25% or higher
- Baseline Numeric Pain Rating Scale (NPRS) score of 3 or higher out of 10
- Low back pain symptoms lasting more than 3 months
- Able to commit to at least six weeks of physical therapy interventions
You will not qualify if you...
- Serious spinal conditions such as acute fracture, active cancer, inflammation, or inflammatory arthropathy
- Low back pain symptoms that radiate below the knee
- Pregnancy
- Diagnosed neurological diseases including traumatic brain injury, multiple sclerosis, chronic regional pain syndrome, or fibromyalgia
- History of spinal surgery
- Currently involved in litigation related to low back pain
- Undergoing Medical Evaluation Board (MEB) process
- Planning to retire or separate from the military within one year
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Brooke Army Medical Center
Fort Sam Houston, Texas, United States, 78234
Actively Recruiting
Research Team
K
Kyle R Petrey, DPT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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