Actively Recruiting
Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2026-03-11
1300
Participants Needed
1
Research Sites
382 weeks
Total Duration
On this page
Sponsors
M
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
H
Heart and Stroke Foundation of Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.
CONDITIONS
Official Title
Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Ejection fraction greater than 35%
- Indication for ventricular pacing with high-degree AV block and anticipated right ventricular pacing over 90%, including third degree AV block, second-degree AV block (symptomatic or asymptomatic), or first degree AV block with specified conduction delays
- Echocardiogram performed within the last 3 months with available DICOM images
You will not qualify if you...
- Need for an implantable cardioverter defibrillator
- Presence of a mechanical tricuspid valve
- Previous attempt at implanting an ICD, CRT, His bundle pacing, or left bundle branch pacing
- Inability to provide informed consent
- Serious medical condition with life expectancy less than 2 years
- Pregnancy
- Expected transient or recoverable conduction system abnormality
- Permanent atrial fibrillation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
McGill University Health Centre-Research Institute
Montreal, Quebec, Canada, H3Y2T6
Actively Recruiting
Research Team
J
Jacqueline Joza, MD MSc
CONTACT
F
Fiorella Rafti, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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