Actively Recruiting
Conebeam CT-based Online Adaptive Radio-Therapy for Esophageal Cancer (ARTEC)
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2024-04-25
30
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Despite multimodal therapy, patients with esophageal cancer have poor prognosis with 5-year overall survival around 25%. Considering tumor-related death as main reason for high mortality rate in those patients, treatment-related cardio-pulmonary toxicities could also play a role in this regard. Online adaptive radiotherapy offers the possibility for daily re-planning and therefore helps radiation oncologists to better spare the organs at risk and reduce radiation-induced toxicity. Tha aim of ARTEC is to assess the pulmonary toxicity in patients with esophageal cancer treated with online adaptive radiotherapy.
CONDITIONS
Official Title
Conebeam CT-based Online Adaptive Radio-Therapy for Esophageal Cancer (ARTEC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Histologically confirmed adenocarcinoma or squamous cell carcinoma of the thoracic esophagus or gastroesophageal junction (Siewert I-II)
- Clinical stage cT2-4b cN0 cM0 or cTany cN+ cM0, or early-stage esophageal cancer not eligible for upfront surgery
- Age 18 years or older
- Karnofsky Performance Status (KPS) at least 70 or ECOG score 0-1
- No psychological, familial, sociological, or geographical conditions that could prevent compliance with the study and follow-up
You will not qualify if you...
- Cervical esophageal cancers (15-18 cm from the incisors)
- Clinical or radiologic evidence of metastatic disease
- Any active cancer within 2 years before study registration that could affect treatment
- Prior thoracic radiotherapy causing overlapping radiation fields
- Pregnant or breastfeeding females
- Induction chemotherapy for current cancer allowed only if last dose was between 10 and 90 days before registration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Inselspital, University of Berne, Deparftment of Radio-Oncology
Bern, Switzerland, 3010
Actively Recruiting
Research Team
H
Hossein Hemmatazad, MD
CONTACT
T
Timo Nannen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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