CONFIRM Study on MRI-Guided Radiation Therapy for Gastric, Breast, Lymphoma, Larynx, and Bladder Cancers

What this Trial Is About

Researchers are evaluating the safety and feasibility of using magnetic resonance imaging MRI guided radiation therapy combined with chemotherapy to treat patients with gastric and breast cancer. This study is a Phase III clinical trial focusing on a special radiation machine called the MRIdian Linear Accelerator. The trial aims to determine if MRI during radiation can help doctors target cancer more precisely, improving treatment delivery. Participants will receive MR-image guided radiation therapy tailored to the specific cancer site following standard treatment guidelines. The study includes screening for eligibility, the treatment itself with ongoing evaluations, follow-up visits, and completion of questionnaires. The trial also considers different cancer types such as gastric cancer, breast cancer, mantle cell lymphoma, larynx cancer, and bladder cancer. Throughout the study, participants will undergo various assessments including tumor evaluation using MRI during treatment, patient-reported outcomes, and monitoring for treatment-related side effects. The primary outcomes involve tumor control over one year and measuring complete pathological response in gastric cancer. Safety and treatment duration will be closely tracked, along with long-term survival and tumor changes observed through MRI. Participation may last up to one year with scheduled follow-up and questionnaires.

CONFIRM: Magnetic Resonance Guided Radiation Therapy