Actively Recruiting
Confirmatory Efficacy Trial of Attention Bias Modification for Depression
Led by University of Texas at Austin · Updated on 2025-09-15
600
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
U
University of Texas at Austin
Lead Sponsor
A
Arcade Therapeutics
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the efficacy of two related, but different ABM (Attention Biased Modification) treatments for depression in adults with elevated symptoms of depression. The main aims are: * Aim 1:examine whether gamified ABM leads to greater change in the primary and secondary outcomes than sham ABM * Aim 1: establish that gamified ABM is at least as effective as traditional ABM. * Aim 2: identify moderators of ABM efficacy and mechanisms responsible for its efficacy. * Aim 3: Identify the durability of ABM on depression symptoms during short-term follow-up Participants will complete self-report questionnaires, complete eye-tracking tasks, and be clinically assessed through interviews by clinician researchers. If there is a comparison group: Researchers will compare sham, traditional, and gamified treatment groups to see if they moderate symptoms of depression.
CONDITIONS
Official Title
Confirmatory Efficacy Trial of Attention Bias Modification for Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided informed consent
- Fluent in English
- Scored 13 or greater on the QIDS-SR at the baseline assessment
- Between the ages of 18 to 70
- Have had no changes in medication and dosage in the past 12 weeks (if currently on antidepressant medication)
You will not qualify if you...
- Reported suicidal behavior or significant suicidal ideation within the past six months using the Columbia-Suicide Severity Rating Scale (C-SSRS)
- Met criteria for current or past bipolar or psychotic disorders
- Current (i.e., within the past 12 months) substance use disorders of moderate or greater severity on the Mini International Neuropsychiatric Interview (MINI)
- Currently taking opioid analgesics or systemic corticosteroid use as these medications
- Currently receiving psychotherapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Institute for Mental Health Research
Austin, Texas, United States, 78705
Actively Recruiting
Research Team
C
Christopher G Beevers, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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