Personalized Deep Brain Stimulation Targeting Specific Brain Circuits for Severe Obsessive-Compulsive Disorder in Adults

What this Trial Is About

This research focuses on people with severe obsessive-compulsive disorder OCD who have not improved after many treatments. The goal is to study deep brain stimulation DBS targeting a specific brain region called the anterior limb of the internal capsule ALIC. Researchers aim to personalize the stimulation to the brain circuits linked to each persons OCD symptoms, improving the effectiveness of DBS by finding the best brain targets for each patient. Participants will have DBS leads implanted in both sides of the ALIC, connected to a device under the skin near the collar bone that controls brain stimulation. Before surgery, patients receive detailed brain scans to plan the best implant locations. After surgery, routine visits will help adjust the stimulation settings and monitor effects. Participants will also undergo EEG recordings at the start of stimulation and after 6 and 12 months, along with behavioral tests every two months while the device stimulates specific brain circuits. During the study, researchers will create personalized brain maps to link stimulation locations with changes in behavior and clinical symptoms. Participants will be assessed monthly for OCD symptom changes using a standard scale, and other mood and behavior measures will be tracked. The total study participation lasts up to 12 months after surgery, including routine clinical visits, brain scans, EEG tests, and behavioral assessments to better understand and optimize DBS for OCD treatment.

Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder