Actively Recruiting
Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
Led by University of Maryland, Baltimore · Updated on 2025-10-07
250
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Maryland, Baltimore
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are developing a whole blood substitute to use when banked blood is not available or suitable. This study focuses on creating a balanced resuscitation fluid that combines artificial components mimicking oxygen carriers, plasma, and platelets to treat both shock and coagulopathy. The goal is to produce a product that can improve care in both civilian and military trauma settings, especially during the critical first hours after injury. The study tests combinations of artificial blood components that have been designed to overcome problems seen in past blood substitutes, such as poor oxygen delivery and harmful effects on blood vessel regulation. These components can be stored dry for long periods and then reconstituted. The study involves healthy adult volunteers who provide blood samples to compare the artificial blood analog's performance with fresh and stored whole blood. Participants will undergo observational study procedures including blood donation and analysis. Researchers will assess how well the artificial blood analog delivers oxygen compared to stored blood over four years. Various laboratory tests will measure physical and functional performance such as hemodynamics and hemostasis. The study is designed to optimize the artificial blood's compatibility and effectiveness while monitoring safety and performance over time.
CONDITIONS
Brief Title
Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject is 18 years of age or older
- Subject weighs more than 40 kilograms (88 pounds)
- Subject must be generally healthy
You will not qualify if you...
- Suspected or diagnosed with ongoing (chronic) or acute infection
- Subject is pregnant
- Subject is non-English speaking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 years
Participants provide blood samples for observational study to analyze artificial blood components.
1 or more visits depending on study schedule
Duration - Up to 4 years
Participants are observed over time to evaluate the performance of blood analogues and oxygen delivery capacity.
Periodic visits as scheduled by the study team
Trial Site Locations
Total: 1 location
1
University of Maryland Baltimore (UMB)
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
S
Stephen Rogers, PhD
T
Tobi Rowden, RN
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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