Comparing Effects of Four Central Venous Catheters on Blood Clotting in Adults A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating how four different types of central venous catheters CVCs affect the bodys blood clotting system. CVCs are thin tubes placed in large veins to give medications, fluids, or take secure blood samples, but they can sometimes cause blood clots, leading to serious health issues. This randomized controlled trial aims to compare the impact on coagulation caused by these commonly used catheters to better understand clot formation after catheter insertion. Participants will be randomly assigned to receive one of four different two-lumen central venous catheters, each made of polyurethane but with different sizes or coatings, including antimicrobial and silver ion-embedded options. Blood samples will be taken twice from each catheter once immediately after insertion without flushing, and once after flushing with saline and discarding the initial blood. These samples will then be tested with rotational thromboelastometry ROTEM and other coagulation tests to compare clotting times and related markers between catheter types and within the overall group. During the study, participants will undergo catheter placement followed by blood sample collection at two specific times. The blood will be processed and analyzed shortly after collection to measure clotting times, clot strength, and various coagulation factors. The main outcome is the change in clotting time between the two samples. This information will help researchers identify how different catheters interact with blood clotting and could lead to safer catheter use and better prevention of clot-related complications. Participants will be monitored throughout the procedure and sample collection process, which is expected to last a short time after catheter insertion.

Contact Activation of Coagulation in Newly Inserted Central Venous Catheters