Actively Recruiting
Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
Led by Iuliu Hatieganu University of Medicine and Pharmacy · Updated on 2026-03-24
93
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether continuous nefopam administration, as part of a multimodal analgesia strategy, reduces opioid consumption and improves patient satisfaction after pancreatoduodenectomy. The main questions are: Does nefopam administration reduce opioid consumption after pancreatoduodenectomy? Does nefopam administration reduce postoperative pain levels after pancreatoduodenectomy? Researchers will compare two other analgesic strategies, namely continuous lidocaine infusion and epidural analgesia, to assess whether they lead to better outcomes. Participants will complete the QoR-15 questionnaire and report their pain levels at predefined time points before and after surgery.
CONDITIONS
Official Title
Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective pancreatoduodenectomy surgery
- Agreed to participate in the study
You will not qualify if you...
- Refusal to participate
- Emergency surgery
- Neurological, muscular, or psychiatric disorders that impair communication
- Known allergic reactions to the medications used
- Known hyperalgesia
- Chronic opioid use
- Need for reintervention within 48 hours postoperatively
- Patients with pancreaticogastrostomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prof. O. Fodor Regional Institute of Gastroenterology and Hepatology
Cluj-Napoca, Cluj, Romania
Actively Recruiting
Research Team
A
Andrei O Mitre
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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