Actively Recruiting
Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia
Led by Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Updated on 2025-07-17
100
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes one of the leading places. Within the ERAS guidelines all sorts of minimization of opioid analgesics use in schemes of postoperative analgesia are appreciated. Thus, new pharmacological approaches are being actively developed currently in order to achieve adequate analgesia and to minimize the use of this group of drugs. One of the most perspective trends within the multimodal analgesia concept is continuous infusion of non-steroidal anti-inflammatory drugs (NSAID). Up to date there are papers that both confirm the effectiveness of this method for maintaining adequate postoperative analgesia and show its limitations and deny the advantages of the continuous use of NSAID. Up to this time the main attention of the medical community was paid for such drugs as paracetamol and ketoprofen. Nevertheless, one of the most common and safe NSAID is ibuprofen. In spite of this, there are no studies that explore the effectiveness of the continuous infusion of this drug. Thus, the lack of even low-quality evidence led to setting up a study of effectiveness and safety of continuous infusion of ibuprofen in comparison to its bolus injection.
CONDITIONS
Official Title
Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Elective laparoscopic surgery
- General anesthesia
- Signed informed consent from the patient to participate in the study
- RASS scale from -2 to +1 on admission to a surgical department or ICU
You will not qualify if you...
- History of ibuprofen allergy
- Active erosive or ulcerative lesions of the gastrointestinal tract
- Chronic use of opioid analgesics or NSAIDs prior to enrollment
- Chronic kidney disease 63 3b stage according to the KDIGO classification
- Liver dysfunction (three times exceeding the upper reference limit of ALT or AST)
- A history of bronchial asthma
- A history of hereditary coagulopathies
- A history of use of anticoagulants
AI-Screening
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Trial Site Locations
Total: 1 location
1
City Clinical Hospital named after S.S. Yudin
Moscow, Moscow Oblast, Russia, 115446
Actively Recruiting
Research Team
V
Valery Likhvantsev, PhD
CONTACT
K
Kristina Kadantseva, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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