Actively Recruiting
Continuous vs Bolus Protein (Protein Regimen Outcomes) in Critically Ill Children (Kids In Distress)
Led by University of British Columbia · Updated on 2026-02-12
96
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this intervention study is to evaluate the difference in nutrition status markers (weight and muscle mass) when giving dietary protein by continuous or bolus delivery in critically ill children ages 1-11y. The main questions it aims to answer are: Primary: Bolus protein delivery will lessen the decline in mid-upper arm circumference (MUAC) z-score by 0.5 standard deviation in critically ill children aged 1-11y after 1wk. Ultrasound will correlate to MUAC. Secondary: Bolus protein delivery will provide more (grams per day) than when provided continuously, therefore it is more likely to meet the minimum estimated needs. Participants will have daily nutrition intake data collected, and undergo body composition measures (weight, MUAC and ultrasound of the upper thigh muscle) at day of enrollment, and MUAC/Ultrasound on follow up days 3, 5, 7 and 14 after the intervention started.
CONDITIONS
Official Title
Continuous vs Bolus Protein (Protein Regimen Outcomes) in Critically Ill Children (Kids In Distress)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children admitted to PICU over 1 year of age and younger than 11 years of life
- Expected to remain in the pediatric intensive care unit for longer than 72 hours
- Receiving standard pediatric formula via nasogastric, orogastric, or gastrostomy tube
You will not qualify if you...
- Neuromuscular condition such as muscular dystrophy
- Admitted with home prescription for high dose steroids, receives growth hormone or insulin
- Enteral nutrition is contraindicated or if nutrition requirements are partially or fully met by parenteral nutrition
- Formula delivered into the small bowel (duodenum or jejunum)
- Requires a highly specialized diet such as for large burns or metabolic diseases
- Has a cow's milk protein allergy and cannot safely receive a whey-based protein supplement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
BC Childrens Hospital
Vancouver, British Columbia, Canada, V6H 3N1
Actively Recruiting
Research Team
K
Kaitlin A Berris, BSc
CONTACT
R
Rajavel Elango, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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