Actively Recruiting
Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
Led by Hassan II University · Updated on 2025-09-09
140
Participants Needed
2
Research Sites
58 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are: * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ? * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.
CONDITIONS
Official Title
Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Full-term, singleton, pregnant women, nonlaboring
- Scheduled for elective cesarean delivery under spinal anesthesia
- American Society of Anesthesiologists physical status 1 or 2
- Baseline systolic blood pressure between 90 and 140 mm Hg
You will not qualify if you...
- Known fetal abnormality
- Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular, or kidney disease
- Contraindication to spinal anesthesia
- Peripartum hemorrhage
- Body mass index above 40 kg/m2
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University hospital Hassan II
Fes, Morocco, 30060
Not Yet Recruiting
2
University hospital Hassan II
Fes, Morocco, 30060
Actively Recruiting
Research Team
M
Mohamed Adnane Berdai, MD-PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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