Actively Recruiting
A Prospective Comparison of Pain and Analgesia in Patients With Continuous Peripheral Nerve Block Catheters Using Continuous Infusion or Scheduled Bolus Infusion
Led by Stanford University · Updated on 2025-12-08
240
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two methods of delivering local anesthetic through peripheral nerve block catheters to manage pain after surgery. This study focuses on continuous infusions versus scheduled bolus infusions of the anesthetic medication Ropivacaine. The goal is to evaluate how these methods affect post-surgical pain, opioid use, recovery quality, and patient satisfaction. The study includes three groups based on different nerve block sites: interscalene, adductor canal, and infraclavicular. Participants will receive either a continuous basal rate of Ropivacaine or scheduled intermittent boluses of the same medication via catheters placed at the nerve block sites. Each group will have 60 patients enrolled, and the treatments are randomly assigned. The study is triple-masked to ensure unbiased results. The use of catheters aims to extend pain relief well into the first few days after surgery. During the study, participants' pain levels will be monitored on post-operative days 0, 1, and 2. Researchers will also track opioid consumption, local anesthetic use, signs of diaphragmatic paralysis, recovery quality, and patient satisfaction during these days. The study is designed to closely observe and compare the effects of the two infusion methods on pain management and recovery after surgery, with a total study duration extending through the early post-operative period.
CONDITIONS
Brief Title
Continuous Infusions vs Scheduled Bolus Infusions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients presenting for nerve block catheters for post-operative analgesia
- ASA physical status I, II, or III
You will not qualify if you...
- Pregnancy
- Incarceration
- Age under 18
- BMI greater than 35
- Pre-operative opioid use greater than 30 mg morphine equivalents per day
- Inability to communicate with investigators by telephone
- Pre-existing neuropathy of the operative extremity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Post-operative day 0 to 2
Participants receive regional anesthesia via a peripheral nerve block catheter using either a continuous infusion or scheduled intermittent bolus of local anesthetic to manage post-operative pain.
Daily visits for 3 days
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
A
Aaron J Deng, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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