Actively Recruiting

Phase 4
Age: 18Years +
All Genders
ID03230565

A Prospective Comparison of Pain and Analgesia in Patients With Continuous Peripheral Nerve Block Catheters Using Continuous Infusion or Scheduled Bolus Infusion

Led by Stanford University · Updated on 2025-12-08

240

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are comparing two methods of delivering local anesthetic through peripheral nerve block catheters to manage pain after surgery. This study focuses on continuous infusions versus scheduled bolus infusions of the anesthetic medication Ropivacaine. The goal is to evaluate how these methods affect post-surgical pain, opioid use, recovery quality, and patient satisfaction. The study includes three groups based on different nerve block sites: interscalene, adductor canal, and infraclavicular. Participants will receive either a continuous basal rate of Ropivacaine or scheduled intermittent boluses of the same medication via catheters placed at the nerve block sites. Each group will have 60 patients enrolled, and the treatments are randomly assigned. The study is triple-masked to ensure unbiased results. The use of catheters aims to extend pain relief well into the first few days after surgery. During the study, participants' pain levels will be monitored on post-operative days 0, 1, and 2. Researchers will also track opioid consumption, local anesthetic use, signs of diaphragmatic paralysis, recovery quality, and patient satisfaction during these days. The study is designed to closely observe and compare the effects of the two infusion methods on pain management and recovery after surgery, with a total study duration extending through the early post-operative period.

CONDITIONS

Brief Title

Continuous Infusions vs Scheduled Bolus Infusions

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients presenting for nerve block catheters for post-operative analgesia
  • ASA physical status I, II, or III
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Incarceration
  • Age under 18
  • BMI greater than 35
  • Pre-operative opioid use greater than 30 mg morphine equivalents per day
  • Inability to communicate with investigators by telephone
  • Pre-existing neuropathy of the operative extremity

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Post-operative day 0 to 2

Participants receive regional anesthesia via a peripheral nerve block catheter using either a continuous infusion or scheduled intermittent bolus of local anesthetic to manage post-operative pain.

Daily visits for 3 days

Trial Site Locations

Total: 1 location

1

Stanford University

Stanford, California, United States, 94305

Actively Recruiting

Loading map...

Research Team

A

Aaron J Deng, BS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Similar Trials

Comparison of Dexamethasone Versus Dexmedetomidine Added to ...

Pain, Postoperative

Actively Recruiting

1 location

Comparison of Postoperative Pain After Application of Aloe V...

Skin Graft Wounds

Actively Recruiting

1 location

Analgesic Efficacy of Different Liposomal Bupivacaine Doses ...

Pain, Postoperative

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here