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Phase 2
Phase 3
Age: 40Years - 80Years
FEMALE
ID07373782

Using CPAP Device to Reduce Heart and Lung Radiation in Breast Cancer Radiotherapy Clinical Study in Women Aged 40 to 80 After Breast Conserving Surgery

Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-01-28

53

Participants Needed

1

Research Sites

26 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating the potential benefits of using continuous positive airway pressure CPAP during radiotherapy for patients with early stage breast cancer who have had breast conserving surgery. The study aims to see if CPAP can reduce radiation exposure to the heart and lungs compared to standard radiotherapy. This may help lower the risk of radiation-related heart and lung problems over time. The study also explores how CPAP can be integrated into daily radiotherapy practice. Participants include women aged 40 to 80 who have invasive or in situ breast cancer requiring radiotherapy. Each patient undergoes CT simulations with and without CPAP support. For left-sided breast cancer patients under 70, a deep inspiration breath hold technique is used, while right-sided cases and patients 70 or older use free breathing. If CPAP reduces radiation doses to the heart or lungs significantly, treatment is given with CPAP. Comfort and treatment accuracy with CPAP are also assessed. During the study, heart and lung radiation doses are closely monitored from enrollment until about eight weeks after treatment ends. Researchers evaluate patient comfort through surveys and check how well CPAP-assisted radiotherapy can be reproduced and delivered accurately. They also measure radiation doses to other areas like the contralateral breast and liver, assess breath hold performance, and study the time-effectiveness of CPAP use. Total participation spans the radiotherapy period plus follow-up assessments.

CONDITIONS

Brief Title

Continuous Positive Airway Pressure (CPAP) Assisted Radiotherapy in Breast Cancer

Research Team

A

Aline Van der Vorst, MD

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