Evaluating CPAP Versus Deep Inspiration Breath Hold to Reduce Tumor Movement During Stereotactic Body Radiation Therapy for Lung Cancer

What this Trial Is About

Researchers are evaluating how two methods, continuous positive airway pressure CPAP and deep inspiration breath hold DIBH, affect tumor movement during stereotactic body radiation therapy SBRT for lung cancer. This pilot phase III trial aims to compare these methods to estimate their ability to reduce tumor motion from normal breathing. The study also assesses whether CPAP might be better tolerated and more time-efficient than DIBH, and how well each method protects normal tissue while covering the tumor during radiation treatment. Participants undergo CT simulation scans during free breathing, DIBH, and CPAP to help plan their treatment. If a patient has trouble exhaling on CPAP, they may receive biphasic positive airway pressure BiPAP scans. The physician reviews these scans to decide the best method for tumor motion control during SBRT. Patients using CPAP or BiPAP wear the device for over an hour before and again during SBRT sessions lasting 30 to 60 minutes. Others complete free breathing or DIBH during their SBRT treatment within the same time frame. Throughout the study, participants are monitored with CT scans to measure tumor motion reduction, lung volume increase, and treatment delivery time differences between CPAP and DIBH. Researchers assess how well patients tolerate the methods and the reproducibility of lung expansion. The main outcome focuses on estimating the decrease in tumor motion within 10 days. The total participation period aligns with the radiation therapy and monitoring schedule, concluding by May 2028.

Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer