Measuring the Effectiveness of a Continuous Positive Airway Pressure Device to Reduce Tumor Motion and Increase Lung Volume Expansion in Patients Undergoing Stereotactic Body Radiotherapy for Tumors That Move With Respiration

What this Trial Is About

Researchers are evaluating how well two different methods—continuous positive airway pressure (CPAP) and deep inspiration breath hold (DIBH)—reduce tumor movement during stereotactic body radiation therapy (SBRT) for patients with lung cancer. This pilot phase I/II trial aims to compare these techniques to see which is better at limiting tumor motion and expanding lung volume, potentially improving radiation targeting. The study also seeks to find out if CPAP is more time-efficient and better tolerated by patients than DIBH. Participants undergo CT simulation scans using free-breathing, DIBH, and CPAP methods. If a patient has difficulty exhaling with CPAP, a biphasic positive airway pressure (BiPAP) simulation is done. The physician then selects the best method for SBRT. If CPAP or BiPAP is preferred, patients wear the device for over one hour before and during the 30-60 minute radiation treatment. Otherwise, patients complete radiation using free-breathing or DIBH techniques over the same time frame. During the study, patients receive various scans and radiation treatments to measure tumor movement and lung volume changes. Researchers monitor treatment time, patient tolerance, and how well normal tissues are spared during therapy. The primary outcome is the decrease in tumor motion measured within 10 days. Secondary outcomes include lung volume increase and radiation delivery time. Participants are observed throughout the treatment, with detailed assessments to evaluate the effectiveness of each tumor motion management method.

Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer