Actively Recruiting
Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
Led by Universitätsklinikum Hamburg-Eppendorf · Updated on 2026-05-13
446
Participants Needed
4
Research Sites
29 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
CONDITIONS
Official Title
Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 45 years or older
- Scheduled for elective major non-cardiac surgery under general anesthesia
- Planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter
- At least two of the following risk factors for acute kidney injury: age 65 years or older, ASA physical status III or IV, chronic arterial hypertension, diabetes mellitus requiring medication, intra-abdominal surgery, preoperative renal insufficiency (serum creatinine 1.2 mg/dL)
You will not qualify if you...
- Pregnancy
- Cardiac arrhythmia
- History of intracranial hemorrhage or intracranial aneurysm
- Clinical need for continuous norepinephrine infusion during anesthesia induction (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
- Unable to understand, read, and provide informed consent in German
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf
Düsseldorf, Germany
Not Yet Recruiting
2
Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, University Hospital Giessen, Justus-Liebig University Giessen
Giessen, Germany
Not Yet Recruiting
3
Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf
Hamburg, Germany
Not Yet Recruiting
4
Department of Anaesthesiology, University Hospital LMU Munich
München, Germany
Actively Recruiting
Research Team
K
Kristen K Thomsen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here