Actively Recruiting
Led by University of California, San Diego · Updated on 2025-06-17
40
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating whether a continuous adductor canal nerve block provides better pain relief and reduces opioid use compared to a single injection nerve block after total knee replacement surgery. This pilot study involves adults undergoing primary, unilateral total knee arthroplasty and aims to compare pain levels, opioid consumption, and physical therapy progress during the first week after surgery. Participants will be randomly assigned to one of two groups: one receiving a single injection of ropivacaine (0.5%) followed by a 5-day continuous infusion of ropivacaine (0.2%) via an OnQ pump device, and the other receiving only the single injection with no continuous infusion. The nerve block is performed before surgery using ultrasound guidance to target the adductor canal near the saphenous nerve. During the study, participants will be monitored for pain intensity using a numeric rating scale, opioid use, and physical and emotional functioning up to 30 days after surgery. Physical therapy milestones will also be tracked to assess recovery. The study includes safety checks for allergies, informed consent capacity, and contact availability, with total participation lasting up to one month postoperatively.
CONDITIONS
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 days
Participants receive a single injection adductor canal nerve block prior to surgery. Those in the experimental group also receive a 5-day continuous perineural infusion using an OnQ pump for postoperative pain management.
1 baseline visit prior to surgery and daily visits for up to 5 days
Duration - 30 days
Participants are monitored for pain scores, opioid consumption, and physical therapy milestones for up to 30 days after surgery.
Follow-up visits or contacts during the 30-day postoperative period
Total: 1 location
1
University of California, San Diego
La Jolla, California, United States, 92037
Actively Recruiting
R
Rodney A Gabriel, MD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Roger Chou, Debra B Gordon, Oscar A de Leon-Casasola...
https://pubmed.ncbi.nlm.nih.gov/26827847