Actively Recruiting
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Led by Unity Health Toronto · Updated on 2026-05-01
60
Participants Needed
1
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.
CONDITIONS
Official Title
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age and older
- Primary osteoarthritis diagnosis with indication for primary elective unilateral total knee arthroplasty
- No previous contralateral knee injections (steroids or biologics) within one year prior to study
- Not scheduled for bilateral total knee arthroplasty or staged contralateral surgery within six months
- No previous or active infection or trauma affecting the contralateral knee
- Contralateral knee pain greater than 4 out of 10 on the Visual Analog Scale at pre-operative visit
- Contralateral knee osteoarthritis graded 2 to 4 on Kellgren and Lawrence scale based on blinded knee X-rays
- Ability to read and understand English and provide informed consent
You will not qualify if you...
- Osteoarthritis from inflammatory or post-traumatic arthritis requiring total knee arthroplasty
- Cognitive impairment such as dementia or delirium preventing completion of outcome measures or follow-up
- Previous total knee arthroplasty, open reduction internal fixation, or nailing on either knee
- Previous or active infection or extensor mechanism disruption in either knee
- Previous arthroscopy on either knee
- Medical reasons preventing elective total knee arthroplasty surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
Research Team
C
Cassandra Tardif-Theriault, BKin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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