Efficacy and Treatment Response of Intra-articular Corticosteroid Injections in Patients With Symptomatic Knee Osteoarthritis.
Elizabeth G Matzkin, Emily J Curry, Qingwu Kong...
https://pubmed.ncbi.nlm.nih.gov/28953085Actively Recruiting
Phase 1
Phase 2
Age: 18Years +
All Genders
ID06809998
COSTI: Contralateral Corticosteroid Injection in Total Knee Arthroplasty - A Triple-Blinded Randomized Controlled Pilot Study
Led by Unity Health Toronto · Updated on 2026-05-01
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether injecting corticosteroids into the knee opposite to the one undergoing total knee arthroplasty (TKA) can improve pain and function for patients with bilateral knee osteoarthritis (OA). This pilot study is a triple-blinded, randomized controlled trial focused on assessing the effectiveness of peri-operative corticosteroid injections compared to a control using a band-aid. The study addresses the problem of residual pain and limited function in the non-operated knee, which can affect patient satisfaction after unilateral TKA. Participants will receive either an injection of 80mg methylprednisolone with bupivacaine into the contralateral knee after spinal anesthesia or a band-aid as a sham comparator. The injection is administered under ultrasound guidance by an anesthesiologist after spinal neuraxial blockage has been given. This intervention aims to reduce inflammation and improve post-operative recovery and rehabilitation without the risks associated with bilateral TKA surgery. During the study, participants will be assessed at 4, 8, 12 weeks and 1 year after surgery using measures including the Oxford Knee Score, Visual Analogue Scale for pain, EuroQol five-dimensional health questionnaire, knee range of motion, Timed Up Go test, and Forgotten Joint Score. Researchers will monitor patient-reported outcomes and functional improvements to determine if the corticosteroid injection provides better results. The study expects to complete by mid-2027.
CONDITIONS
Brief Title
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age and older
- Diagnosed with primary osteoarthritis and scheduled for primary elective unilateral total knee arthroplasty
- No corticosteroid or biologic injections in the opposite knee within one year prior to the study
- Not scheduled for bilateral or staged contralateral total knee arthroplasty within the next six months
- No previous or active infection or trauma in the opposite knee
- Opposite knee pain with a Visual Analogue Scale score greater than 4 out of 10 at initial pre-operative visit
- Opposite knee osteoarthritis graded between 2 and 4 by Kellgren and Lawrence scale
- Able to read and understand English and provide informed consent
You will not qualify if you...
- Osteoarthritis due to other causes such as inflammatory or post-traumatic arthritis
- Cognitive impairment preventing completion of outcome measures or follow-up
- Previous total knee arthroplasty, open reduction internal fixation, or nailing on either knee
- Previous or active infection or extensor mechanism damage in either knee
- Previous arthroscopy on either knee
- Medical contraindications to elective total knee arthroplasty surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single day
Participants receive either a corticosteroid injection or a sham band-aid application in the contralateral knee during the surgery visit, alongside their total knee arthroplasty procedure.
1 visit (in-person)
Follow-up
Duration - Up to 1 year post-surgery
Participants are monitored for recovery and outcomes including knee function, pain, and quality of life after surgery.
Visits at 4, 8, 12 weeks and 1 year post-surgery
Trial Site Locations
Total: 1 location
1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
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Research Team
C
Cassandra Tardif-Theriault, BKin
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Published Research Related To This Trial
Intra-articular Corticosteroids for Osteoarthritis of the Knee.
Bruno R da Costa, Roman Hari, Peter Jüni
https://pubmed.ncbi.nlm.nih.gov/28027351Intra-articular injection of methylprednisolone for reducing pain in knee osteoarthritis: A systematic review and meta-analysis.
Kewei Tian, Huiguang Cheng, Jiangtao Zhang...
https://pubmed.ncbi.nlm.nih.gov/29642145Comparison of clinical outcome between simultaneous-bilateral and staged-bilateral total knee arthroplasty: a systematic review of retrospective studies.
Dong Fu, Guodong Li, Kai Chen...
https://pubmed.ncbi.nlm.nih.gov/23518424Safety of simultaneous bilateral total knee arthroplasty. A meta-analysis.
Camilo Restrepo, Javad Parvizi, Thomas Dietrich...
https://pubmed.ncbi.nlm.nih.gov/17545424Bilateral Simultaneous vs Staged Total Knee Arthroplasty: A Comparison of Complications and Mortality.
Dhiren S Sheth, Guy Cafri, Elizabeth W Paxton...
https://pubmed.ncbi.nlm.nih.gov/27430183Functional outcomes of simultaneous bilateral versus unilateral total knee arthroplasty.
Deren Bagsby, Jeffery L Pierson
https://pubmed.ncbi.nlm.nih.gov/25611419Postoperative Stiffness Requiring Manipulation Under Anesthesia Is Significantly Reduced After Simultaneous Versus Staged Bilateral Total Knee Arthroplasty.
John P Meehan, Shafagh Monazzam, Troy Miles...
https://pubmed.ncbi.nlm.nih.gov/29257014Patient Dissatisfaction Following Total Knee Arthroplasty: A Systematic Review of the Literature.
Rajitha Gunaratne, Dylan N Pratt, Joseph Banda...
https://pubmed.ncbi.nlm.nih.gov/28844632The rate and predictors of patient satisfaction after total knee arthroplasty are influenced by the focus of the question: a standard satisfaction question is required.
N D Clement, M Bardgett, D Weir...
https://pubmed.ncbi.nlm.nih.gov/29855236