Actively Recruiting
Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
Led by University of Colorado, Denver · Updated on 2026-02-04
100
Participants Needed
1
Research Sites
77 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study plans to learn more about using contrast enhanced ultrasound (CEUS) in brain tumor surgery. The goal of glioma brain tumor surgery is to remove as much of the glioma as possible. Tumor tissue that is close to normal brain tissue can look very similar. This can make it difficult for the surgeon to remove all the tumor. In this study, we hope to learn if using CEUS during brain tumor surgery will allow the brain surgeon to better see and remove all the tumor tissue.
CONDITIONS
Official Title
Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to sign and date the consent form
- Willing to comply with all study procedures and be available for the study duration
- Male or female aged 18 to 95 years
- Planned standard of care surgery for presumed primary or known recurrent glioma
- WHO performance status of 2 or less (or Karnofsky Performance Status of 70 or higher)
- Negative pregnancy test within 14 days before inclusion for patients of childbearing potential
You will not qualify if you...
- High risk of surgical site infection (e.g., 2 or more previous craniotomies/neurosurgery in last 3 months, poor skin condition, previously infected surgical field, or other increased infection risk per neurosurgeon)
- Known allergy to perflutren lipid microsphere components or inactive ingredients in the contrast agent
- Known or suspected active or chronic infections
- Significant cardiac disease, right-to-left shunts, severe pulmonary hypertension (pulmonary artery pressure over 90 mm Hg), uncontrolled systemic hypertension, or adult respiratory distress syndrome
- Pregnant or breastfeeding
- Known sickle cell disease
- Any serious medical or psychological condition interfering with safe treatment and care
- Under legal guardianship, curatorship, legal protection, or deprived of liberty by administrative or judicial decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
J
Jen Maitlen, BSN
CONTACT
T
Terra Ornelas, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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