Evaluating Contrast-Enhanced Ultrasound and Super-Resolution Imaging to Predict Kidney Function After Partial or Radical Nephrectomy in Renal Cell Cancer Patients

What this Trial Is About

Researchers are evaluating how advanced imaging techniques, specifically Contrast-Enhanced Ultrasound CEUS and Super-Resolution Imaging SRI, can predict kidney function outcomes in patients with renal cell carcinoma undergoing either partial or radical nephrectomy. This prospective cohort study focuses on whether these imaging methods can forecast long-term kidney function and the occurrence, severity, and early recovery from postoperative acute kidney injury AKI. The study aims to provide new imaging biomarkers to support personalized care and early treatment decisions after nephrectomy. Participants will undergo CEUS and SRI examinations before surgery and at specific times afterward to visualize kidney blood flow and microvascular structures. The study will monitor changes in both the affected and healthy kidneys. Blood and urine samples will be collected during hospitalization for kidney function tests. Follow-up visits will occur at 1, 3, 6, 9, and 12 months post-surgery, including imaging assessments like CT or ultrasound to track recovery. During the study, researchers will collect clinical data, imaging results, and laboratory tests to analyze the relationship between imaging parameters and kidney function outcomes. The primary outcomes include measuring new baseline estimated glomerular filtration rate eGFR and recovery from ischemia 12 months after surgery. The study will also observe kidney blood flow and microvascular density changes over time to understand their link to AKI and long-term kidney health.

Contrast-enhanced Ultrasound and Super-resolution Imaging Predict Renal Function Outcome After Nephrectomy