Actively Recruiting

Phase Not Applicable
Age: 20Years +
All Genders
NCT07550790

Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure

Led by Seoul National University Bundang Hospital · Updated on 2026-04-24

190

Participants Needed

1

Research Sites

143 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75 mL/min/1.73 m²). Patients requiring contrast-enhanced CT imaging are randomized to either standard intravenous saline hydration or a furosemide-based decongestion strategy. Renal function is assessed using serial measurements of creatinine and cystatin C, before and after contrast exposure. By comparing renal outcomes, congestion status, and safety profiles, this study aims to determine whether a decongestion-focused approach provides superior renal protection compared with conventional hydration in high-risk acute heart failure patients.

CONDITIONS

Official Title

Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure

Who Can Participate

Age: 20Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 20 years or older
  • Emergency department visit or hospitalization for acute heart failure with clinical evidence of congestion
  • Planned contrast-enhanced computed tomography during the current hospitalization
  • Baseline renal dysfunction with an estimated glomerular filtration rate (eGFR) between 30 and 75 mL/min/1.73 m²
Not Eligible

You will not qualify if you...

  • Need for vasopressor therapy
  • Need for renal replacement therapy (dialysis)
  • Known allergy or hypersensitivity to furosemide
  • Ongoing acute coronary syndrome
  • Pregnant or breastfeeding women, or women of childbearing potential without a negative pregnancy test
  • High potassium levels (serum potassium >5.5 mmol/L)
  • Uncorrected low blood volume or low sodium levels (serum sodium <130 mmol/L)
  • Any condition that investigators consider makes study participation inappropriate

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea, 13620

Actively Recruiting

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Research Team

J

Jin Joo Park, MD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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