Actively Recruiting
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
Led by University Hospital, Toulouse · Updated on 2025-09-22
440
Participants Needed
11
Research Sites
323 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Toulouse
Lead Sponsor
C
Centre de recherche Cerveau et Cognition (CERCO)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as measured by freedom from disabling seizures one-year post-surgery. 220 patients (for whom 4-6 usual clinical macro-electrodes will be replaced by hybrid micro-macro electrodes and for whom fast-ripples will be assessed) distributed over 5 centres and 220 control patients(who will undergo an SEEG with the usual electrodes and for whom fast-ripples will not be assessed) distributed over 6 centres. This is a controlled, non-randomized, parallel plan, prospective, multicentre exploratory study.
CONDITIONS
Official Title
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient suffering from drug-resistant focal epilepsy (DRFE), as defined by the International League Against Epilepsy, undergoing SEEG selected by a multidisciplinary epilepsy meeting
- Patient who has given written informed consent for study data collection
- Patient covered by the French healthcare system
You will not qualify if you...
- Patients under juridical protection (authorship, curatorship, or safeguarding of justice)
- Patient deprived of liberty by judicial or administrative decision
- Patient with a cardiac defibrillator
- Thermocoagulation planned on any potential hybrid electrode
- Patient currently in exclusion period of another study
- Patients not meeting criteria for SEEG
AI-Screening
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Trial Site Locations
Total: 11 locations
1
CHU Amiens Picardie
Amiens, France
Actively Recruiting
2
University hospital of Bordeaux
Bordeaux, France, 33076
Actively Recruiting
3
University hospital of Grenoble Alpes
La Tronche, France, 38700
Actively Recruiting
4
APHP Hôpital Bicêtre
Le Kremlin-Bicêtre, France, 94270
Actively Recruiting
5
CHU de Lille
Lille, France
Actively Recruiting
6
Hospices Civils de Lyon
Lyon, France
Actively Recruiting
7
CHRU de Nancy
Nancy, France
Actively Recruiting
8
Fondation Adolphe de Rothschild
Paris, France, 75019
Not Yet Recruiting
9
CHU de Rennes
Rennes, France
Actively Recruiting
10
Hôpitaux universitaires de Strasbourg
Strasbourg, France
Actively Recruiting
11
University Hospital of Toulouse
Toulouse, France, 31059
Actively Recruiting
Research Team
L
Luc VALTON, MD
CONTACT
Y
Yoan HERADES
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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