Using Indocyanine Green Angiography to Detect Parathyroids and Prevent Hypoparathyroidism After Total Thyroidectomy Surgery

What this Trial Is About

Hypoparathyroidism is a common complication following total thyroidectomy surgery, often temporary but sometimes permanent if lasting beyond six months. Permanent hypoparathyroidism requires lifelong replacement therapy and significantly impacts quality of life. This trial evaluates the use of indocyanine green ICG angiography during surgery to detect parathyroid glands and potentially reduce postoperative hypoparathyroidism rates. Participants are randomly assigned to one of two groups the ICG group receiving two or three intraoperative injections of 5 mg ICG during thyroidectomy, and the control group undergoing traditional surgery with visual detection of parathyroids. Both groups are followed for six months after surgery to monitor outcomes. During the study, researchers will assess blood calcium levels to detect hypocalcemia, examine the rate of definitive hypoparathyroidism at various time points up to six months, and evaluate the ability of ICG angiography to detect and preserve parathyroid glands. Safety and tolerance of ICG are also monitored. The primary outcome is the frequency of hypocalcemia two days after surgery, with several secondary outcomes tracked over time.

Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy