Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07112820

Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses

Led by Fondation Hôpital Saint-Joseph · Updated on 2025-08-08

100

Participants Needed

1

Research Sites

127 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Patients with myocardial infarction require invasive treatment involving coronary angiography to confirm the diagnosis and, in most cases, treatment by angioplasty/stenting. Trans-thoracic ultrasound is central to the initial management of patients admitted to hospital with acute coronary syndrome without ST segment elevation. The aim of our study is therefore to compare perfusion ultrasound with coronary angiography and MRI in this population in order to determine whether the performance is satisfactory.

CONDITIONS

Official Title

Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient over 18 years of age
  • Hospitalised in cardiology as an emergency for acute coronary syndrome without ST segment elevation with indication for coronary angiography within 72 hours of admission
  • Not yet undergone coronary angiography
  • Troponin above 99th percentile (greater than 27 ng/l)
  • Presence of new segmental kinetic disorder on transthoracic echocardiography or ECG repolarisation disorder outside ST elevation
  • Patient affiliated with a health insurance scheme
  • French-speaking patient
  • Patient who has given free, informed, and written consent
Not Eligible

You will not qualify if you...

  • Haemodynamically unstable patient: heart rate over 100 and/or systolic blood pressure under 90 mmHg and/or diastolic blood pressure under 60 mmHg and/or oxygen saturation below 92% in ambient air and/or clinical signs of hypoperfusion (such as mottling or cyanosis)
  • Rhythmically unstable patient: sustained ventricular tachycardia or recovered sudden death
  • Known allergy to ultrasound contrast medium
  • Patient with ST segment elevation
  • Contraindication to MRI
  • Symptoms suggestive of myocarditis (fever and/or significant inflammatory syndrome with CRP over 50 mg/l)
  • Already included in a type 1 interventional research protocol
  • Patients under guardianship, curatorship, judicial protection, or deprived of liberty
  • Pregnant or breastfeeding patients (negative pregnancy test required for women of childbearing age)

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Hospital Paris Saint-Joseph

Paris, Ilede France, France, 75014

Actively Recruiting

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Research Team

Y

Yoann MOEUF, medical doctor

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

0

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