Actively Recruiting
Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses
Led by Fondation Hôpital Saint-Joseph · Updated on 2025-08-08
100
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients admitted with acute coronary syndrome without ST segment elevation often undergo invasive coronary angiography to confirm myocardial infarction and guide treatment such as angioplasty or stenting. This research aims to evaluate whether myocardial perfusion imaging using contrast-enhanced ultrasound can accurately diagnose myocardial infarction or other heart conditions compared to coronary angiography and MRI. The study focuses on improving diagnosis while potentially reducing the need for invasive procedures. The study involves performing perfusion ultrasound using a contrast agent called Sonovue®, which enhances imaging by mimicking red blood cells in the blood flow. This ultrasound method allows real-time assessment of blood flow in the heart muscle and is compared against coronary angiography and MRI results. Patients with acute coronary syndrome without ST elevation who meet specific clinical criteria will be examined using this technique within 72 hours of hospital admission. Participants will undergo transthoracic echocardiography with perfusion ultrasound, coronary angiography, and possibly MRI. Researchers will review ultrasound images, clinical data, and other test results to determine diagnostic accuracy. The main outcome measured is the sensitivity and specificity of the ultrasound test for diagnosing myocardial infarction. The study will monitor safety and diagnostic performance during the initial hospital phase, with results based on expert cardiologist consensus.
CONDITIONS
Brief Title
Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient over 18 years of age
- Hospitalised in cardiology as an emergency for acute coronary syndrome without ST segment elevation with indication for coronary angiography within 72 hours of admission
- Not yet undergone coronary angiography
- Troponin greater than 99th percentile (greater than 27 ng/l)
- Presence of new segmental kinetic disorder on transthoracic echocardiography or ECG repolarisation disorder outside ST elevation
- Patient affiliated with a health insurance scheme
- French-speaking patient
- Patient who has given free, informed, and written consent
You will not qualify if you...
- Haemodynamically unstable patient (heart rate over 100, systolic blood pressure under 90 mmHg, diastolic blood pressure under 60 mmHg, oxygen saturation under 92% in ambient air, or signs of hypoperfusion)
- Rhythmically unstable patient (sustained ventricular tachycardia, recovered sudden death)
- Known allergy to ultrasound contrast medium
- Patient with ST segment elevation
- Patient with contraindication to MRI
- Patient with signs of myocarditis (fever or high inflammatory markers)
- Patients already included in a type 1 interventional research protocol
- Patients under guardianship, curatorship, judicial protection, or deprived of liberty
- Pregnant or breastfeeding patients (negative pregnancy test required for women of childbearing age)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 72 hours after admission
Participants undergo myocardial perfusion imaging using contrast-enhanced ultrasound to assess heart muscle blood flow and help diagnose acute coronary syndromes without ST elevation.
1 visit (in-person)
Duration - Within 72 hours after admission
Participants receive coronary angiography to confirm diagnosis and guide treatment if needed.
1 visit (in-person)
Duration - As needed during hospital stay
Selected participants may undergo cardiac MRI to further confirm or rule out myocardial infarction when coronary angiography findings are inconclusive.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Hospital Paris Saint-Joseph
Paris, Ilede France, France, 75014
Actively Recruiting
Research Team
Y
Yoann MOEUF, medical doctor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
0
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