Actively Recruiting

Age: 40Years - 89Years
All Genders
Healthy Volunteers
NCT04513782

The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss

Led by University of Colorado, Denver · Updated on 2023-08-15

200

Participants Needed

1

Research Sites

295 weeks

Total Duration

On this page

Sponsors

U

University of Colorado, Denver

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Age-related hearing loss, presbycusis, affects up to 50% of American adults. There are two main causes for presbycusis: 1) Progressive death of hair cells in the inner ear, and 2) Central hearing loss, or the reduced ability to decipher the sound source of interest from other competing sounds in a multi-source complex environment. The first cause is better understood and treatment options, such as hearing aids and cochlear implants, are available. However, central hearing loss is not as well understood and there is not a treatment available at this time. This study aims to advance our understanding of central hearing loss by evaluating the abilities of younger and older listeners in two primary outcome measures: to 1) neurologically process sound stimuli and 2) focus on conversational speech in the presence of spatially-separated competing background noise. A test using Auditory Brainstem Responses (ABR) will be used to evaluate the brain's response to clicking sounds. This study will assess all waveform data, but will focus particularly on wave III. Sentence in noise tests will be used to assess each subject's ability to process speech in noisy situations. Both the ABR and sentence in noise tests are non-invasive and are commonly used in audiology practices to diagnosis and treat a variety of audiological pathologies.

CONDITIONS

Official Title

The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss

Who Can Participate

Age: 40Years - 89Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 21 and 89 years inclusive
  • Hearing loss no worse than mild, defined as hearing thresholds no worse than 40 dBHL at any test frequency 250-4000 Hz based on pure tone audiometry
  • Score of 26 or higher on the Montreal Cognitive Screening Assessment (MoCA)
Not Eligible

You will not qualify if you...

  • Age outside the range of 21 to 89 years
  • Air-bone gap greater than 10 dBHL at any frequency
  • Unable to complete speech perception testing due to decisional challenges
  • Little command of English, unable to understand and repeat simple everyday English sentences
  • Illiteracy
  • Diagnosis of neurodegenerative diseases

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Colorado School of Medicine

Aurora, Colorado, United States, 80045

Actively Recruiting

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Research Team

S

Shaylene Denham

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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