Actively Recruiting
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
Led by Morten H. Bestle · Updated on 2025-02-06
1000
Participants Needed
24
Research Sites
395 weeks
Total Duration
On this page
Sponsors
M
Morten H. Bestle
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.
CONDITIONS
Official Title
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute admission to the intensive care unit
- Age 18 years or older
- Fluid overload of 5% or more of ideal body weight, including fluids given before ICU admission if possible
- Clinically stable with mean arterial pressure over 50 mmHg, noradrenaline infusion no higher than 20 microgram/kg/min, and lactate below 4.0 mmol/L
You will not qualify if you...
- Known allergy to furosemide or sulphonamides
- Advanced chronic kidney disease before hospitalization (eGFR less than 30 mL/min/1.73 m2 or chronic renal replacement therapy)
- Currently receiving renal replacement therapy
- Anuria lasting more than 6 hours
- Rhabdomyolysis requiring forced diuresis
- Ongoing life-threatening bleeding
- Acute burn injury affecting more than 10% of body surface
- Severe sodium imbalance (p-Na less than 120 or greater than 155 mmol/L)
- Severe liver failure
- Patients under forced treatment
- Fertile women under 50 years with positive pregnancy test (urine or plasma hCG)
- Consent not obtainable as per trial site model
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Department of Intensive Care, Liverpool Hospital
Sydney, Australia
Not Yet Recruiting
2
Department of Intensive Care, Sygehus Sønderjylland Aabenraa
Aabenraa, Denmark
Actively Recruiting
3
Departmen of Intensive Care
Aalborg, Denmark, 9000
Actively Recruiting
4
Department of Intensive Care, Aarhus University Hospital
Aarhus, Denmark
Terminated
5
Department of Intensive Care, Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
6
Departement of Intensive Care, Gentofte Hospital
Gentofte Municipality, Denmark
Terminated
7
Department of Intensive Care, Herlev Hospital
Herlev, Denmark, 2730
Actively Recruiting
8
Department of Intensive Care, Regionshospital Gødstrup
Herning, Denmark, 7400
Actively Recruiting
9
Department of Intensive Care, Nordsjællands hospital
Hillerød, Denmark, 3400
Actively Recruiting
10
Department of Intensive Care, Regionshospital Nordjylland Hjørring
Hjørring, Denmark
Actively Recruiting
11
Department of Intensive Care
Kolding, Denmark, 6000
Actively Recruiting
12
Department of Intensive Care, Zealand University hospital
Køge, Denmark, 4600
Actively Recruiting
13
Department of Intensive Care
Odense, Denmark, 5000
Actively Recruiting
14
Department of Intensive Care, Regionshospitalet Randers
Randers, Denmark, 8930
Actively Recruiting
15
Department of Intensive Care, University Hospital Zealand, Roskilde
Roskilde, Denmark
Actively Recruiting
16
Department of Intensive Care
Vejle, Denmark, 7100
Withdrawn
17
Regionshospitalet Viborg
Viborg, Denmark, 8800
Actively Recruiting
18
Department of Intensive Care, Tampere University Hospital
Tampere, Finland, 33520
Terminated
19
Department of Intensive Care
Turku, Finland
Terminated
20
Department of Intensive Care, Landspitali National University Hospital of Iceland
Reykjavik, Iceland
Terminated
21
Department of Critical Care, University Medical Center Groningen
Groningen, Netherlands
Actively Recruiting
22
Department of Intensive Care, Ålesund Sjukehus
Ålesund, Norway
Terminated
23
Department of Intensive Care, Stavanger University Hospital
Stavanger, Norway, 4068
Terminated
24
Department of Intensive Care, Inselspital
Bern, Switzerland
Actively Recruiting
Research Team
S
Sine Wichmann, MD
CONTACT
M
Morten Bestle, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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