Actively Recruiting

Phase 4
Age: 18Years - 44Years
FEMALE
NCT04487925

Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders

Led by University Hospital, Ghent · Updated on 2024-05-09

208

Participants Needed

1

Research Sites

153 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a prospective, randomized, single center, phase 4 controlled trial. The study will compare the efficacy of two different strategies for the management of predicted poor response patients under stimulation for IVF/ICSI: up to three MNC cycles (group 1) versus a single GnRH antagonist CFA (group 2).

CONDITIONS

Official Title

Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders

Who Can Participate

Age: 18Years - 44Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Signed informed consent form
  • Age 18 to under 45 years
  • Body Mass Index (BMI) between 18.5 and under 35 Kg/m²
  • Regular menstrual cycles between 21 and 35 days
  • Two ovaries present
  • Current wish to become pregnant
  • Poor responders as defined by POSEIDON criteria: Group 3 (under 35 years with poor ovarian reserve) or Group 4 (35 years or older with poor ovarian reserve)
Not Eligible

You will not qualify if you...

  • Participation in another clinical study
  • Untreated or uncontrolled thyroid dysfunction
  • Tumors of the ovary, breast, uterus, pituitary, or hypothalamus
  • Abnormal vaginal bleeding without known cause
  • Ovarian cysts or enlarged ovaries
  • Malformations of reproductive organs
  • Current use of oral contraceptives, antipsychotics, antiepileptics, or chemotherapy
  • Previous antibiotic hypersensitivity to streptomycin or neomycin
  • Undergoing preimplantation genetic testing (PGT), fertility preservation, or oocyte donation

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University Hospital Ghent

Ghent, Belgium, 9000

Actively Recruiting

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Research Team

S

Sara Somers, MSc

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders | DecenTrialz